525 Novel peptide from commensal Staphylococcus simulans blocks MRSA quorum sensing and protects host skin from damage
The human skin is colonized by a diverse array of bacteria, archaea, fungi, and viruses. Recent studies highlight the abundance of commensal coagulase-negative staphylococci (CoNS) as well as the relative absence of methicillin resistant Staphylococcus aureus (MRSA) on healthy skin. A widely recognized mechanism of bacterial competition is the quorum sensing Accessory Gene Regulator (agr) system, ubiquitous among staphylococci. We hypothesize that agr signaling facilitates interspecies cross-talk between CoNS and MRSA, resulting in a colonization advantage for CoNS and protecting the host from MRSA colonization or infection.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: M.M. Brown, D. Todd, N. Cech, A. Horswill Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research
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