550 Efficacy and toxicity of hypofractionated adjuvant radiotherapy in Merkel cell carcinoma

Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer. Conventional post-operative radiotherapy (cPORT), given in 25-30 fractions (2Gy per fraction) over 5-6 weeks, is associated with improved locoregional control but also with skin toxicity, fibrosis, and wound healing issues. We hypothesized that 1-3 fractions of 8Gy hypofractionated PORT (hPORT), may provide adequate control in the majority of patients with significantly diminished toxicity and a less extensive treatment regimen. 17 patients with locoregional MCC were identified from our prospective registry that received hPORT after an informed discussion that included cPORT versus receiving no RT.

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: M.M. Cook, S.K. Schaub, S. Park, D.S. Hippe, J.J. Liao, S. Apisarnthanarax, S. Bhatia, P.T. Nghiem, Y.D. Tseng, U. Parvathaneni Tags: Interventional Studies, Clinical and Patient Outcomes Research Source Type: research