647 Basis for the link between atopic dermatitis and autism

A subset of patients with autism spectrum disorders (ASD) have a prior history of atopic dermatitis (AD). Moreover, the prevalence of ASD increases dramatically as AD phenotypes worsen. In a standard ASD animal model (parenteral administration of valproic acid [VPA] to second trimester pregnant mice), we explored the basis for the baseline association, and second, for the AD phenotype-dependent increase in ASD prevalence. At birth, VPA-treated mice demonstrated extensive neuro- and epidermal cytotoxicity, but no evidence of inflammation.

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: K. Shin, K. Park, S. Jeong, B. Park, Y. Uchida, J. Wakefield, D. Crumrine, J. Meyer, P.M. Elias Tags: Neuro-Cutaneous Biology and Inflammation Source Type: research