650 IL-31 produced by Th17 cells contributes to psoriasiform dermatitis

IL-31 is an IL-6 family cytokine usually associated with allergic inflammation and itch. IL-31 expression is detectable in blood and lesional skin from atopic dermatitis patients, and can be induced by Th2-polarization of mouse or human CD4 T cell clones in vitro. Recently, IL-31 expression has also been reported in non-Th2 itchy inflammatory skin conditions such as cutaneous T cell lymphoma, dermatomyosis, and psoriasis. In psoriasis, IL-31 mRNA expression has not been mapped to any specific cell type.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Neuro-Cutaneous Biology and Inflammation Source Type: research