654 Mechanisms of itch, allergy and neurogenic inflammation: Substance P functions through Mrgprs

Neurogenic inflammation encompasses atopic dermatitis, allergy, inflammation and itch. Mas-related G-protein coupled receptors (Mrgprs) are increasingly recognized as critical to neurogenic inflammation. Substance P (SP) is an established mediator of neurogenic inflammation. Our hypothesis is that SP mediates its effects through MrgprA1. To test this hypothesis, we determined that neurons which respond to SP express MrgprA1. Furthermore, neurons from MrgprA1-/- mice generated using CRISPR/cas9 did not respond to SP.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Neuro-Cutaneous Biology and Inflammation Source Type: research