827 CuxS-controlled chemotherapeutics release and photothermal- photodynamic therapeutic strategy to inhibit progression and metastasis of melanoma by eliciting immunogenic cell death

Conventional monotherapies only benefit a minority of melanoma patients while combined immunotherapy exhibited extremely high rates of treatment-related adverse events. Herein, we created a multifunctional and immunogenic nanoplatform, AuNR@mSiO2@DOX-CuxS-PEG, which integrating photothermal properties of gold nanoparticles, photodynamic properties of CuxS and chemotherapy into a single nanoplatform. Upon near-infrared laser irradiation (NIR), the CuxS were uncapped and triggered chemotherapy drugs release into tumor environment.

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: Y. Zhang, C. Guo, J. Zhu, J. Tao Tags: Pigmentation and Melanoma Source Type: research