865 Frontal fibrosing alopecia is associated with dysregulation of cholesterol biosynthesis pathways, fibrosis and mast cells

Frontal Fibrosing Alopecia (FFA) is a lymphocytic cicatricial alopecia that predominantly occurs in post-menopausal women. It is characterized by a band-like loss of hair and follicular ostia of the frontal temporal scalp, and commonly involves bilateral eyebrow loss. Over the last 15 years the incidence of FFA has shown a noticeable, albeit unexplained rise. Current accepted treatment is based on expert opinion and includes steroids, hormone blockers, and hydroxychloroquine. To delineate the transcriptional landscape of FFA, we performed RNAseq on scalp biopsies of 18 FFA patients compared with controls.

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: B. Sallee, E.H. Wang, J.C. Chen, J. Lavian, L.A. Bordone, A. Christiano Tags: Skin, Appendages, and Stem Cell Biology Source Type: research