878 Keratin 17 upregulate the expression of CXCL1 in human psoriastic keratinocyte cells through going the nucleus

Keratin 17(K17), as a cytoskeletal protein, is highly expressed in epithelial cells of inflammatory skin diseases and various tumor tissues. In recent years, the present of K17 in the nucleus was found in several tumors. However, such phenomenon had not been documented in inflammatory dermatoses. In our present study, K17 translocation into the nucleus of keratinocytes in psoriasis were found. Thus, greater insight into the mechanism of K17 translocation and its pathogenicity were explored. Initially, we found that K17 occurs as discrete punctate and/or in a diffuse pattern in the nucleus of keratinocytes in psoriastic lesion.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Skin, Appendages, and Stem Cell Biology Source Type: research