907 Propionibacterium acnes and peptidoglycan reduce lipidgenesis and change differentiation of SZ95 human sebocytes in vitro via aryl hydrocarbon receptor

Individual lesions in acne vulgaris exist spontaneous remission, which is related to shrunken and de-differential sebaceous gland (SGs) in comedone with unknown mechanisms. P. acnes stimulated by increased lipids from SGs plays key role in acne pathogenesis, while the relationship between the P. acnes and SGs is still a myth. We explored the action of P. acnes and peptidoglycan (PGN) on the effects of lipidgenesis and differentiation of cultured SZ95 human sebocytes. Firstly, we observed that both formaldehyde-inactivated P.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Skin, Appendages, and Stem Cell Biology Source Type: research