949 Single cell RNA-seq and single cell ATAC-seq analyses during a treatment for dystrophic epidermolysis bullosa
Dystrophic epidermolysis bullosa (DEB) is a one of the most severe form of EB caused by mutations in COL7A1 (coding type VII collagen). DEB patients, without functional type VII collagen, suffer from the repetitive blistering and have high risk of early-onset aggressive squamous cell carcinoma. Recently, we found that a fragment of HMGB1 activates an endogenous tissue regeneration mechanism and ameliorates the DEB related manifestations in a DEB model mouse. This HMGB1 treatment model in the DEB mouse serves as a unique opportunity to investigate on how the skin can lose the integrity by loss of a single protein and how the damaged skin can be reconstructed.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: T. Shimbo, S. Yamazaki, T. Kitayama, Y. Ouchi, R. Yamamoto, E. Takaki, Y. Kikuchi, L. Bruckner-Tuderman, J. Uitto, Y. Kaneda, K. Tamai Tags: Tissue Regeneration and Wound Healing Source Type: research
More News: Cancer & Oncology | Carcinoma | Dermatology | Epidermolysis Bullosa | Skin | Skin Cancer | Squamous Cell Carcinoma