1033 The potential pro-proliferative role of polo-like kinase 4 in non-melanoma skin cancer

Nonmelanoma skin cancers (NMSC), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are the most common cancers in the United States, with over 5.4 million cases diagnosed annually. Current therapeutic strategies and preventative measures have not been able to effectively manage this neoplasm. Therefore, better understanding of NMSC biology may provide novel mechanisms and targets for management of these cancers. Polo-like kinase 4 (PLK4) is a serine/threonine kinase, known to play a role in cell division by regulating centriole duplication.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Translational Studies Source Type: research