1039 Novel mouse model of recessive dystrophic epidermolysis bullosa-squamous cell carcinoma
The high frequency and extremely aggressive behavior of squamous cell carcinoma from recessive dystrophic epidermolysis bullosa patients (RDEB-cSCC), as well as the lack of an appropriate preclinical mouse model recapitulating the RDEB-cSCC phenotype for testing effective therapies/drugs, creates an urgent need for generating such a model. Here, we established a novel mouse model for RDEB-cSCC, in which we generated 3D cSCC skin constructs (SCs) using RDEB-cSCC and RDEB fibroblasts (FB), which were then grafted onto immunocompromised mice.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: J. Jackow, C. Hansen, R. Hayashi, D. Owens, R. Perez-Lorenzo, D. Delorenzo, Z. Guo, A. Christiano Tags: Translational Studies Source Type: research
More News: Cancer & Oncology | Carcinoma | Dermatology | Epidermolysis Bullosa | Skin | Skin Cancer | Skin Graft | Squamous Cell Carcinoma | Study