Erythropoietin does not improve fracture healing in aged mice.

Conclusion: In fracture healing of aged mice EPO treatment increases callus TMD as well as OPG and RANKL expression, indicating an accelerated bone turnover when compared to controls. However, EPO does not improve fracture healing in aged mice. The process of fracture healing may be altered by EPO due to a deterioration of the microcirculation caused by the worsened rheological properties of the blood and due to an increased bone fragility caused by the accelerated bone turnover. Thus, EPO may not be used to improve fracture healing in the elderly. PMID: 30998964 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30998964?dopt=Abstract

Source: Experimental Gerontology - April 14, 2019 Category: Geriatrics Authors: Orth M, Baudach J, Scheuer C, Osche D, Veith NT, Braun BJ, Rollmann MF, Herath SC, Pohlemann T, Menger MD, Histing T Tags: Exp Gerontol Source Type: research