MedImmune spinoff scores breakthrough status for rare autoimmune disease treatment

Viela Bio Inc. has earned a breakthrough therapy designation from the Food and Drug Administration for a product to treat neuromyelitis optica spectrum disorder, a life-threatening autoimmune disease that impacts the central nervous system. The FDA granted breakthrough status to the company’s candidate, inebilizumab, following positive results from a pivotal study that was “the largest monotherapy study ever conducted in NMOSD,” said Dr. Jorn Drappa, chief medical officer and head of research…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news

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Publication date: Available online 28 April 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Atul Gawande, Gaurav K. Gupta, Ankit Gupta, Shashank J. Wanjari, Vasudha Goel, Vinay Rathore, Hemendra Bhardwaj, Sandeep NijhawanBackground and AimsThe present study is planned to assess etiologies, course, and outcome in patients with acute-on-chronic liver failure (ACLF).MethodsTwo hundred and eight (182 males and 26 females) patients of ACLF fulfilling modified Asia Pacific Association For Study Of Liver Consensus criteria 2009 admitted to the gastroenterology department of SMS Medical College and hospital, ...
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
ConclusionsIn conclusion, this is the first study to describe a large single-center pediatric cohort of patients affected with SIgAD, revealing that overall most patients do well with regard to infections. Many develop CD, at a rate much higher than the general population. A few normalize their IgA levels. A few progress to CVID. Thus, careful follow-up is suggested to diagnose and treat potential complications earlier for avoiding potential morbidities.
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research
Abstract Background and purpose: The incidence and prevalence of autoimmune encephalitis is gradually increasing. This retrospective observational study primarily aimed to analyze the clinical characteristics of autoimmune encephalitis patients in the Second Xiangya Hospital and report patient prognoses after immunotherapy. Methods: The clinical data of 86 patients who were diagnosed with autoimmune encephalitis from October 2014 to September 2018 were collected, and their corresponding clinical characteristics, laboratory examination, treatment, and outcome data analyzed. Results: In our study, 72 patients (83.7%) wer...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ConclusionUsing pharmacological compounds that selectively inhibit pro-survival proteins to induce apoptosis in MSCs, we show that mouse and human bone marrow (BM) MSCs engage different molecules for survival. In addition, we are genetically manipulating the apoptotic pathways in mouse and human BM MSCs to gain a greater understanding of how these cells exert their therapeutic effects in vivo, an outstanding question in MSC therapy.
Source: Cytotherapy - Category: Cytology Source Type: research
This study confirms the critical role of PLA2s in arthritis and unveils the distinct contribution of cPLA2α and sPLA2-IIA to the eicosanoid profile in arthritis.
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
Authors: Eleftheriadis T, Pissas G, Zarogiannis S, Liakopoulos V, Stefanidis I Abstract Silicosis is an occupational fibrotic lung disease, which is associated with an increased incidence of autoimmune diseases. The effect of crystalline silica on the immune system is thought to be mediated by the antigen presenting cells. However, the direct effect of silica on T-cells and B-cells has not been evaluated adequately. For this purpose, CD4(+)T-cells and B-cells from 10 healthy individuals were isolated and cultured with or without Min-U-Sil 5. Cell proliferation was assessed with BrdU assay. In cell proliferation exp...
Source: Autoimmunity - Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
CONCLUSION: ARFI elastography can evaluate fibrosis in AIH, PSC and PSC-/PBC-AIH-overlap syndrome with good accuracy for the detection of hepatic cirrhosis. Shear wave velocities in PBC should be interpreted with caution in early stages of fibrosis. PMID: 31113596 [PubMed - in process]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
In conclusion, this clinical case highlights the importance of prompt diagnosis and therapeutics for sclerosing cholangitis secondary to IgG4-related disease in order to avoid progression of the disease and development of liver cirrhosis, as well as the refractory, aggressive nature of the disease in some cases as this one. PMID: 31113593 [PubMed - in process]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
Authors: Maeda R, Naito D, Adachi A, Shiraishi H, Sakamoto T, Matoba S Abstract A 61-year-old Japanese man with IgG4-related autoimmune pancreatitis developed a mass in the right atrium (RA) and a mass lesion surrounding the left anterior descending coronary artery. We performed an intracardiac echo catheter-guided percutaneous biopsy of the RA mass, and histologically diagnosed it as IgG4-related disease. Oral corticosteroid therapy gradually downsized the mass lesions. We encountered a very rare case with mass lesions in the cardiovascular system of the IgG4-related disease that were able to be diagnosed using an...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Authors: Palomino-Lescano H, Segura-Chávez D, Quispe-Orozco D, Castro-Suarez S, De la Cruz W, Zapata-Luyo W, Delgado-Ríos J, Cam J, Alvarado-Morales M, Paredes-Carcasi L, Cornejo-Herrera I, Meza-Vega M Abstract Autoimmune encephalitis with antibodies against the N-methyl-D-aspartate receptor (anti-NMDAR) is a disorder mediated by antibodies against neural surface antigens, whose early diagnosis and timely treatment improve the prognosis of the disease. Four cases with the definitive diagnosis of autoimmune encephalitis by anti-NMDAR are presented, treated at the National Institute of Neurological Scie...
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
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