Effects of N-methylpyrrolidone and temperature on phenytoin solubility

In this study, the solubility of phenytoin in N-methylpyrrolidone (NMP) + water mixtures was determined and the generated data were correlated with the Jouyban-Acree model and its combination with Hansen solubility parameters and Abraham solvation parameters. Moreover, solubilization ratio of phenytoin in 10% of various cosolvents showed a considerable increase and a significant correlation between logarithm of solubilization ratio and hydrogen binding parameters was observed (R2 > 0.9). Despite NMP, temperature could not significantly increase the solubility of phenytoin in NMP + water mixtures against water. The results of this study indicated that NMP is a good solubilizing agent for phenytoin and applied mathematical models could predict solubility of phenytoin with a good accuracy in cosolvent + water mixtures.
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research