Developments in the space of new MAPK pathway inhibitors for BRAF-mutant melanoma.

Developments in the space of new MAPK pathway inhibitors for BRAF-mutant melanoma.
Clin Cancer Res. 2019 Apr 16;:
Authors: Cohen JV, Sullivan RJ
Abstract
The characterization of the MAPK signaling pathway has led to the development of multiple promising targeted therapy options for a subset of patients with metastatic melanoma. The combination of BRAF and MEK inhibitors represents an FDA-approved standard of care in patients with metastatic and resected BRAF mutated melanoma. There are currently three FDA-approved BRAF/MEK inhibitor combinations for the treatment of patients with BRAF mutated melanoma. While there have been significant advances in the field of targeted therapy, further exploration of new targets within the MAPK pathway will strengthen therapeutic options for patients. Important clinical and translational research focuses on mechanisms of resistance, predictive biomarkers, and challenging patient populations such as those with brain metastases or resected melanoma.
PMID: 30992297 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - April 15, 2019 Category: Cancer & Oncology Authors: Cohen JV, Sullivan RJ Tags: Clin Cancer Res Source Type: research