Molecules, Vol. 24, Pages 1546: The Anti-Inflammatory Role of Mannich Curcuminoids; Special Focus on Colitis

Molecules, Vol. 24, Pages 1546: The Anti-Inflammatory Role of Mannich Curcuminoids; Special Focus on Colitis Molecules doi: 10.3390/molecules24081546 Authors: Gábor J. Szebeni Lajos I. Nagy Anikó Berkó Alexandra Hoffmann Liliána Z. Fehér Mária Bagyánszki Beáta Kari József A. Balog László Hackler Iván Kanizsai Anikó Pósa Csaba Varga László G. Puskás The incidence of inflammatory bowel disease (IBD) increases gradually in Western countries with high need for novel therapeutic interventions. Mannich curcuminoids, C142 or C150 synthetized in our laboratory, have been tested for anti-inflammatory activity in a rat model of TNBS (2,4,6-trinitrobenzenesulphonic acid) induced colitis. Treatment with C142 or C150 reduced leukocyte infiltration to the submucosa and muscular propria of the inflamed gut. C142 or C150 rescued the loss of body weight and C150 decreased the weight of standard colon preparations proportional with 20% less tissue oedema. Both C142 and C150 curcumin analogues caused 25% decrease in the severity of colonic inflammation and haemorrhagic lesion size. Colonic MPO (myeloperoxidase) enzyme activity as an indicator of intense neutrophil infiltration was 50% decreased either by C142 or C150 Mannich curcuminoids. Lipopolysaccharide (LPS) co-treatment with Mannich curcuminoids inhibited NF-κB (nuclear factor kappa B) activity on a concentration-dependent manner in an NF-κB-driven luciferase exp...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research