Molecules, Vol. 24, Pages 1547: A Water-Soluble Microencapsulated Milk Thistle Extract as Active Ingredient for Dermal Formulations

Molecules, Vol. 24, Pages 1547: A Water-Soluble Microencapsulated Milk Thistle Extract as Active Ingredient for Dermal Formulations Molecules doi: 10.3390/molecules24081547 Authors: Tiziana Esposito Francesca Sansone Paola Russo Patrizia Picerno Rita Patrizia Aquino Franco Gasparri Teresa Mencherini The choice of formulation is often of crucial importance in order to obtain a pharmaceutical product for the administration of poorly soluble drugs. Recently, a new water-soluble microparticulate powder form (MTE-mp) for the oral administration of a high functionality/low solubility silymarin rich milk thistle extract (MTE) has been developed. Findings showed that extract-loaded microparticles by spray-drying were produced with high and reproducible yields and encapsulation efficiency. The in vitro dissolution and permeation rates of silymarin were dramatically improved with respect to the raw material, and also enhanced the silymarin anti-inflammatory abilities. Given these successful results, the new MTE-mp delivery system has been proposed as an active ingredient for dermal applications. The aim of this research was the design and development of two topical formulations, hydrogel and emulgel (O/W emulsion), containing the MTE-mp delivery system or MTE raw extract. All the formulations were compared to each other in terms of handling and incorporation amount of the active ingredient during the productive process. Moreover, the addition to the emulgel of lecit...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research