Synthesis and biological evaluation of piperidyl benzimidazole carboxamide derivatives as potent PARP-1 inhibitors and antitumor agents

Publication date: Available online 18 April 2019Source: Chinese Chemical LettersAuthor(s): Xinwei Zhang, Cunlong Zhang, Lin Tang, Kuan Lu, Huan Zhao, Weibin Wu, Yuyang JiangABSTRACTWe have synthesized a series of compounds based on a piperidyl benzimidazole carboxamide structure, and tested their PARP-1 inhibitory activity, as well as cellular inhibitory activity. Some of them show great potency as PARP-1 inhibitors and antitumor activity, which are valuable for further research. In addition, the predicted ADME properties and proposed binding mode with PARP-1 of the compounds were obtained via computational simulation.Graphical AbstractWe have synthesized a series of compounds based on a piperidyl benzimidazole carboxamide structure. Some of them show great potency as PARP-1 inhibitors and antitumor activity.

Source: Chinese Chemical Letters - April 19, 2019 Category: Chemistry Source Type: research