Endometriosis.

Endometriosis. Endocr Rev. 2019 Apr 17;: Authors: Bulun SE, Yilmaz BD, Sison C, Miyazaki K, Bernardi L, Liu S, Kohlmeier A, Yin P, Milad M, Wei J Abstract Pelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including the ovaries. It is caused when shed endometrial tissue travels retrograde into the lower abdominal cavity. Endometriosis is the most common cause of chronic pelvic pain in women and is associated with infertility. The underlying pathologic mechanisms in the intracavitary endometrium and extra-uterine endometriotic tissue involve defectively programmed endometrial mesenchymal progenitor/stem cells. While endometriotic stromal cells, which compose the bulk of endometriotic lesions, do not carry somatic mutations, they demonstrate specific epigenetic abnormalities that alter expression of key transcription factors. For example, GATA-binding factor-6 overexpression transforms an endometrial stromal cell to an endometriotic phenotype, and steroidogenic factor-1 overexpression causes excessive production of estrogen, which drives inflammation via pathologically high levels of estrogen receptor-β. Progesterone receptor deficiency causes progesterone resistance. Populations of endometrial and endometriotic epithelial cells also harbor multiple cancer-driver mutations, such as KRAS, which may be associated with the establishment of pelvic endometrios...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research

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Authors: Turan AS, Ultee G, Van Geenen EJM, Siersema PD Abstract INTRODUCTION: The most commonly used treatment for advanced colorectal adenomas is endoscopic mucosal resection (EMR). The increased number of EMRs since the introduction of the screening program for colorectal cancer has resulted in an increase in EMR-related complications. This review summarizes the current knowledge for the use of clips for the treatment and prevention of complications after EMR. Areas covered: The historical development of clips is summarized and their properties are evaluated. An overview is presented of the evidence for therapeu...
Source: Expert Review of Medical Devices - Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research
Chem. Commun., 2019, Advance Article DOI: 10.1039/C9CC01506J, CommunicationYuan Ma, Quanbing Mou, Lijuan Zhu, Yue Su, Xin Jin, Jing Feng, Deyue Yan, Xinyuan Zhu, Chuan Zhang Polygemcitabine nanogels assembled from DNA-like polygemcitabine undergo rapid intracellular degradation to generate active gemcitabine derivatives for enhanced cancer therapy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
AbstractObjectiveTo evaluate factors associated with use of patient navigation in a prostate cancer population and identify whether navigation is associated with prolonged  time to care. Cancer patient navigation has been shown to improve access to cancer screening, diagnosis, and treatment, but little is known about patient navigation in prostate cancer care.MethodsAll men diagnosed with localized prostate cancer between 2009 and 2015 were abstracted from the MaineHealth  multi-specialty tumor registry. Regression analyses controlling for patient-, disease-, and system-level factors evaluated characteristics ass...
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionIn conclusion, this study illustrates that the application and benefits of HS on reducing GI rectal dose endpoints and toxicities during prostate cancer RT can be reliably replicated in a community setting similar to centres participating in the randomised trial under high quality assurance trial monitoring.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionThere is a need to enhance a constant patient –HCP dialogue, and both groups need to make a conscious effort in that direction. This would help in increasing patients’ awareness of risks, having better treatment choice and acceptance, and reducing side-effects.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Ulnar-sided carpometacarpal (CMC) joint fracture dislocations are relatively uncommon, frequently associated with fractures of the metacarpal base and/or hamate, and often sustained by young male individuals secondary to striking a hard object. The complexity of ulnar-sided CMC fracture dislocations necessitates careful restitution of anatomic alignment and joint congruency for mobility and stability. Miniaturization of the external fixation device has allowed application to the hand. Spanning external fixation utilizes the principles of “ligamentotaxis”—indirect reduction through distraction forces of ca...
Source: Techniques in Hand and Upper Extremity Surgery - Category: Surgery Tags: Techniques Source Type: research
(copied from reddit) Hey guys, So I wanted to follow up on a previous thread I started, which discussed some obstacles and hardships I faced as an undergrad, which included losing my mom to cancer over the course of 2 years. In short, this left me broken mentally, physically, and a scar on my academic career. My GPA was significantly impacted and it decreased incredibly through those years, however, the past 3... What to do next? Graduate and kind of lost right now
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Nontraditional Students Source Type: forums
So my MCAT was logged in for May 31st, but my genius self decided to play basketball yesterday and rolled my ankle yesterday. I have a fracture in the tarsal dome and my ankle is bruised up and swollen like a ball so I'm guessing ligament damage as well. I am in a lot of pain and can't even concentrate on studying because of my foot, I was thinking of moving my test to June 15th just to give me time to readjust. Would this be to late for the cycle? Any help appreciated!!
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pre-Medical - MD Source Type: forums
Lisfranc ligament injuries are not so common and often overlooked. If missed, they can cause long-term disability and pain. The treatment of these injuries are still controversial and very little is known about which types of injury can be treated without surgery. Successful surgical management of these injuries is predicated on anatomic reduction and stable fixation. Open reduction and internal fixation remains the standard treatment, although ligament reconstruction has emerged as a viable option for certain types of tarsometatarsal joint injuries. This paper describes the authors’ approach to treat Lisfranc’...
Source: Techniques in Foot and Ankle Surgery - Category: Orthopaedics Tags: Special Focus: Innovations in Foot and Ankle Sports Injury Treatment Source Type: research
Ankle sprains are one of the most common injuries in foot and ankle, and the superior fascicle of the anterior talofibular ligament (ATFL) frequently is injured as a consequence. Patients with isolated rupture of ATFL’s superior fascicle can sustain a subtle ankle instability or ankle microinstability. Patients with symptomatic ankle microinstability may describe a subjective feeling of ankle instability, recurrent symptomatic ankle sprains, chronic anterolateral pain or a combination of any of them. When conservative management fails, anatomic all-inside ATFL’s superior fascicle repair under direct arthroscopi...
Source: Techniques in Foot and Ankle Surgery - Category: Orthopaedics Tags: Special Focus: Innovations in Foot and Ankle Sports Injury Treatment Source Type: research
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