Cause-and-Effect Relationship Between FGFR1 Expression and Epithelial-Mesenchymal Transition in EGFR-Mutated Non-Small Cell Lung Cancer Cells

Lung cancer remains the leading cause of cancer-related death worldwide, with a disappointing five-year survival rate of approximately 15% [1]. Due to the advanced stage at the time of diagnosis, the prognosis is often poor, and therapeutic options are limited. The presence of multiple metastases renders surgical resection inadequate, and resistance to treatment is a growing problem. Non-small cell lung cancer (NSCLC) represents the most common group of lung cancer (approximately 80% of cases), and activating mutations in receptor tyrosine kinases (RTKs), e.g., in the Epidermal Growth Factor Receptor (EGFR) gene, are frequently observed driver mutations in NSCLC [2].

Source: Lung Cancer - April 17, 2019 Category: Cancer & Oncology Authors: Johan Vad-Nielsen, Kristine Raaby Gammelgaard, Tina Fuglsang Daugaard, Anders Lade Nielsen Source Type: research