Improved Lovastatin Production by Inhibiting (+)-Geodin Biosynthesis in Aspergillus terreus.

This study thus shows that suppression of the (+)-geodin pathway increases lovastatin yield and demonstrates a practical approach of manipulating carbon flux by modulating enzyme activity. PMID: 30995533 [PubMed - as supplied by publisher]
Source: New Biotechnology - Category: Biotechnology Authors: Tags: N Biotechnol Source Type: research

Related Links:

Abstract The human host comprises a range of specific niche environments. In order to successfully persist, pathogens such as Aspergillus fumigatus must adapt to these environments. One key example of in-host adaptation is the development of resistance to azole antifungals. Azole resistance in A. fumigatus is increasingly reported worldwide and the most commonly reported mechanisms are cyp51A mediated. Using a unique series of A. fumigatus isolates, obtained from a patient suffering from persistent and recurrent invasive aspergillosis over 2 years, this study aimed to gain insight into the genetic basis of in-host...
Source: Fungal Genetics and Biology - Category: Biology Authors: Tags: Fungal Genet Biol Source Type: research
Abstract The goal of the study was to compare the production of secondary metabolites by Aspergillus terreus ATCC 20542 under the conditions of submerged mono- and co-cultivation. The suggested experimental scheme encompassed a diverse set of co-culture initiation strategies differing mostly with respect to the development stage of tested fungal strains at the moment of their confrontation. Three species of filamentous fungi exhibiting distinct patterns of morphological evolution under submerged conditions, namely Penicillium rubens, Chaetomium globosum, and Mucor racemosus, were selected as the co-cultivation par...
Source: Applied Microbiology and Biotechnology - Category: Microbiology Authors: Tags: Appl Microbiol Biotechnol Source Type: research
This study revealed that AFB1 disrupts hepatic mitochondrial lipids and antioxidant capacity. These changes were dependent on the timing of exposure and did not follow a linear time-course trend. These alterations could be part of the hepatic mitochondria response mechanism to acute AFB1 toxicity. Aflatoxin B1; Liver; Mitochondria; Lipid; Cholesterol; Thioredoxin reductase; oxidative stress
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion Lactobacillus pentosus was the predominant species found at industrial scale in Spanish table olives biofilms, albeit certain genotypes of L. plantarum were also detected. At genotype level, biodiversity was higher in the Spanish-style table olive biofilms than in those of directly brined olives. The multivariate analysis based on technological and probiotic data showed that the main 16 genotypes obtained could be clustered in 3 great phenotypes, with some strains with potential application as multifunctional starters (especially L. pentosus Lp13 and LpG1 genotypes). Data obtained in the present study showed th...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Izabella Pereira da Silva Bezerra1†, Gabriel Oliveira-Silva1†, Danielle Sophia Ferreira Santos Braga1, Mirian França de Mello1, Juliana Elena Silveira Pratti1, Joyce Carvalho Pereira1, Alessandra Marcia da Fonseca-Martins1, Luan Firmino-Cruz1, Diogo Maciel-Oliveira1, Tadeu Diniz Ramos1, André Macedo Vale1, Daniel Claudio Oliveira Gomes2, Bartira Rossi-Bergmann1 and Herbert Leonel de Matos Guedes1,3* 1Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil 2Núcleo de Doenças Infecciosas/Núcleo de Biotecnologia,...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
In conclusion, this Research Topic includes a wide range of interdisciplinary research work contributing to the ultimate goals of augmenting the existing knowledge and fostering the scientific field of ethnopharmacology in Central and Eastern Europe, as well as globally. This research topic successfully gathered comprehensive interdisciplinary information in the field of ethnopharmacology from the field surveys to standardization and elucidation of molecular mechanisms of action of natural products. Moreover, with consideration of the existing challenges in the field of drug discovery form medicinal plants, this research t...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 10 January 2019Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Virginia Sara Grancieri do Amaral, Caroline Mota Fernandes, Mário R. Felício, Aline Sol Valle, Paula G. Quintana, Caroline Correa de Almeida, Eliana Barreto-Bergter, Sónia Gonçalves, Nuno C. Santos, Eleonora KurtenbachAbstractPsd2 is a pea defensin with 47 amino acid residues that inhibits the growth of fungal species by an uncharacterized mechanism. In this work, Psd2 interactions with model membranes mimicking the lipid compositions of different organisms were evaluated. Prote...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
AbstractMicroorganisms were isolated from industrial wool scouring effluents and from the soil adjacent to the wastewater treatment lagoon, both sterols-rich environments, in order to search for novel biocatalysts able to transform cholesterol. The isolates were identified on the basis of morphological and biochemical characteristics and phylogenetic analysis. Furthermore, a rapid and accurate bacteria identification by matrix assisted laser desorption/ionization-time-of-flight mass spectrometry was carried out. Bacteria and fungi including representatives of the generaFusarium, Talaromyces, Trichoderma, Mucor, Aspergillus...
Source: World Journal of Microbiology and Biotechnology - Category: Microbiology Source Type: research
Abstract Koji, which is manufactured by proliferating non-pathogenic fungus Aspergillus oryzae on steamed rice, is the base for Japanese traditional fermented foods. We have revealed that koji and related Japanese fermented foods and drinks such as amazake, shio-koji, unfiltered sake and miso contain abundant glycosylceramide. Here, we report that feeding of koji glycosylceramide to obese mice alters the cholesterol metabolism . Liver cholesterol was significantly decreased in obese mice fed with koji glycosylceramide. We hypothesized that their liver cholesterol was decreased because it was converted to bile acid...
Source: Bioscience, Biotechnology, and Biochemistry - Category: Biochemistry Authors: Tags: Biosci Biotechnol Biochem Source Type: research
In conclusion, this study shown excellent compatibility of A. oryzae DIA-MF using aguamiel as an economical substrate for the FOS production under a simple bioprocess.
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
More News: Aspergillus | Biotechnology | Carbohydrates | Cardiology | Cholesterol | Genetics | Heart | Lactose | Lovastatin | Science | Study