A facile synthesis of cajaninstilbene acid and its derivatives

Publication date: Available online 17 April 2019Source: Chinese Chemical LettersAuthor(s): Qi Chen, Kuo Lu, Chang Zheng, Xiao-Fang Xu, Jing Lin, Wei-Min ChenAbstractA four-step synthesis of methyl 6-formyl-2-hydroxy-4-methoxy-3-(3-methylbut-2-en-1-yl) benzoate (11) that can be used as building block for a facile synthesis of cajaninstilbene acid and its derivatives is reported. The synthesis of cajaninstilbene acid was accomplished in six steps with an overall yield of 20% starting from commercial materials by a synthesis whose key steps are TiCl4-mediated [3 + 3] cyclization and McMurry coupling.Graphical abstractA facile synthesis of cajaninstilbene and its derivatives by using a building block has been developed.

Source: Chinese Chemical Letters - April 19, 2019 Category: Chemistry Source Type: research