High-throughput exploration of the network dependent on AKT1 in mouse ovarian granulosa cells.

This study also allowed us to put forward new direct and indirect targets of the kinase. Indeed, a series of proteins involved in intracellular transport and mitochondrial physiology were significantly affected by Akt1depletion. Using in silicoanalyses, we also propose a set of kinases and transcription factors that can mediate the action of AKT1 on the deregulated transcripts and proteins. Taken altogether, our results provide a resource of direct and indirect AKT1 targets in granulosa cells and may help understand its roles in this ovarian cell type.
PMID: 30992313 [PubMed - as supplied by publisher]

Source: Molecular and Cellular Proteomics : MCP - April 15, 2019 Category: Molecular Biology Authors: Elzaiat M, Herman L, Legois B, Léger T, Todeschini AL, Veitia RA Tags: Mol Cell Proteomics Source Type: research