Enantioselective iridium catalyzed α-alkylation of azlactones by a tandem asymmetric allylic alkylation/aza-Cope rearrangement.

Enantioselective iridium catalyzed α-alkylation of azlactones by a tandem asymmetric allylic alkylation/aza-Cope rearrangement.
Chem Commun (Camb). 2019 Apr 17;:
Authors: Bai XD, Zhang QF, He Y
Abstract
The development of an iridium catalyzed enantioselective α-alkylation of azlactones has been described. The reaction provides rapid access to a wide range of enantio-enriched quaternary carbon center allylated 2,4-diaryloxazol-5(2H)-ones in excellent yields with high enantioselectivities. The transformation was achieved through a tandem allylic alkylation/aza-Cope rearrangement, affording the desired products under mild conditions. Ultimately, the resulting products could be readily converted into diverse enantio-enriched derivatives which highlight the importance of the methodology.
PMID: 30993284 [PubMed - as supplied by publisher]

Source: Chemical Communications - April 16, 2019 Category: Chemistry Authors: Bai XD, Zhang QF, He Y Tags: Chem Commun (Camb) Source Type: research