Gastroesophageal reflux and serum biomarkers in systemic sclerosis ‐related interstitial lung disease. Reply
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Conclusions: Treatment with biologics affects the cytokine profile in inflammatory synovial fluid in patients with both AS and RA. Furthermore, IL-23 and IL-17 cytokine might be an important factor in some patients who are unresponsive to biologics in AS. PMID: 31830775 [PubMed - as supplied by publisher]
Chikungunya (CHIK) fever is a tropical arbovirosis characterized by sudden fever, headache, rash, and severe arthralgia. The disease has been suggested to act as a trigger for several autoimmune disorders, especially rheumatoid arthritis. This abstract reports 2 cases of Sj ögren syndrome (SS) following CHIK infection. Both patients were female and presented with fever, arthralgia, rash, and arthritis during CHIK outbreak in Recife, Brazil. After several months, they developed severe sicca symptoms and 1 of them presented with parotid enlargement.
Scleroderma is a rare autoimmune disease of unknown etiology characterized by the acumination of collagen in the tissues, which can be divided into localized and systemic. The localized one occurs more in the skin and rarely intraorally. Patient M.S.O., 45 years old and white, was referred to the stomatology clinic presenting painful symptomatology on the left side palate. In her anamnesis, she reported fibromyalgia. Intraoral examination revealed leukoplastic plaques on the palate in a "saber-throb" pattern and the tongue.
We describe 2 cases of dental erosion and 1 case of erythematous lesions in the oral cavity associated with GERD. Case 1 involves a 33-year-old male patient diagnosed as having GERD who presents intense dental erosion in several teeth.
The aim of this study was to report the effect of low-level laser therapy for xerostomia control in a patient with scleroderma. A 7-year-old female patient with medical history of scleroderma was attended with dry and rigid appearance of facial skin and xerostomia. Baseline stimulated salivary flow was assessed before and after treatment. Low-level laser therapy was performed by xerostomia with 6 intraoral points at sublingual glands, 10 points at parotid glands, and 8 points at submandibular glands with 808 nm, 100 mW, and 0.8 J for 8 seconds at each point.
This study aimed to tracing a clinical and histomorphologic profile of these disorders and compare with the data collected in other Brazilian and world populations.
Introduction: it is controversial if gastroesophageal reflux (GER) is involved in etiology and severity of interstitial lung disease (ILD) associated to connective tissue disease (CTD).Objectives: evaluate the frequency of GER in ILD associated to CTD and correlate GER to CTD type, ILD severity and imaging pattern.Methods: multicenter historical cohort study. Patients with ILD associated to CTD attended in 4 hospitals, were evaluated. Variables: age, gender, type of CTD, GER symptoms (pyrosis, regurgitation), high resolution scan (HRCT) ILD pattern and esophagus dilatation, forced vital capacity (FVC), DLCO.Results: n=70, ...
Interstitial lung disease is the leading cause of death in systemic sclerosis (SSc). Despite this, many transplant programs exclude SSc patients from transplantation consideration due to concern for gastroesophageal reflux induced pulmonary injury via a dilated esophagus. Recent studies that examined lung transplantation outcomes in SSc patients do not support this categorical exclusion. We investigated the esophageal diameter on high-resolution computed tomography (HRCT) of the thorax that is associated with ILD in patients with SSc.
Interstitial lung disease is the leading cause of death in systemic sclerosis (SSc) . Despite this, many transplant programs exclude SSc patients from transplantation consideration due to concern for gastroesophageal reflux induced pulmonary injury via esophageal dysfunction . Recent studies that examined lung transplantation outcomes in SSc patients do not support this categorical exclusion . We investigated the esophageal diameter on high-resolution computed tomography (HRCT) of the thorax that is associated with ILD in patients with SSc.