Response of Glucocorticoid Receptor Alpha and Histone Deacetylase 2 to Glucocorticoid Treatment Predicts the Prognosis of Sudden Sensorineural Hearing Loss.

Conclusion: A lack of GRα and HDAC2 induction following steroid treatment in GC-resistant SSNHL patients may play a fundamental mechanistic role in GC insensitivity. Response of GRα and HDAC2 to steroid treatment may, thus, predict the prognosis of hearing improvement in SSNHL patients.
PMID: 30993958 [PubMed - as supplied by publisher]

Source: Clinical and Experimental Otorhinolaryngology - April 18, 2019 Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research