Application of Herbal Traditional Chinese Medicine in the Treatment of Acute Kidney Injury

Conclusion and Perspectives Collectively, previous studies showed that numerous types of TCMs protect against AKI via different mechanisms of action, including inhibiting inflammation, cell apoptosis, necroptosis, ferroptosis, and restraining oxidative stress etc. These data support the potential application of these TCMs as novel therapeutic agents in treating patients with AKI. Although some TCMs have entered preclinical trials, it is essential to initiate pre-clinical pharmacologic and toxicologic trials and clinical trials to evaluate the efficacy and safety of TCMs usage. Moreover, considering that some TCMs are deleterious to the kidney, they should be attracted more attention when utilized. In addition, it is believed that western medicines always relieve symptoms quickly while TCMs exert therapeutic effects gently and fundamentally. In this regard, the combination of TCMs and western medicines may become a promising treatment strategy for AKI by taking advantages of both and by limiting side effects. The interaction between medicines should also be considered. In conclusion, from a holistic point of view, TCM-based anti-AKI therapy should be emphasized and extensively explored, as this may help to minimize the morbidity and mortality of AKI and prolong the survival of patients. Author Contributions JL, XM, and CH designed the theme and direction of the manuscript. LZ and XL critically revised the manuscript. HL drafted the manuscript. Funding This study was suppo...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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