Application of Herbal Traditional Chinese Medicine in the Treatment of Acute Kidney Injury

Conclusion and Perspectives Collectively, previous studies showed that numerous types of TCMs protect against AKI via different mechanisms of action, including inhibiting inflammation, cell apoptosis, necroptosis, ferroptosis, and restraining oxidative stress etc. These data support the potential application of these TCMs as novel therapeutic agents in treating patients with AKI. Although some TCMs have entered preclinical trials, it is essential to initiate pre-clinical pharmacologic and toxicologic trials and clinical trials to evaluate the efficacy and safety of TCMs usage. Moreover, considering that some TCMs are deleterious to the kidney, they should be attracted more attention when utilized. In addition, it is believed that western medicines always relieve symptoms quickly while TCMs exert therapeutic effects gently and fundamentally. In this regard, the combination of TCMs and western medicines may become a promising treatment strategy for AKI by taking advantages of both and by limiting side effects. The interaction between medicines should also be considered. In conclusion, from a holistic point of view, TCM-based anti-AKI therapy should be emphasized and extensively explored, as this may help to minimize the morbidity and mortality of AKI and prolong the survival of patients. Author Contributions JL, XM, and CH designed the theme and direction of the manuscript. LZ and XL critically revised the manuscript. HL drafted the manuscript. Funding This study was suppo...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Source: The American Journal of Surgery - Category: Surgery Source Type: research
ConclusionOverall, these guidelines provide consistent recommendations on who should receive breast reconstruction education, who is a candidate for postmastectomy breast reconstruction, and the appropriate timing of reconstruction and extent of mastectomy. Future updates from all should focus on expanding to include alloplastic and autologous forms of reconstruction and should include a broad scope of relevant questions.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
This study, therefore, aims to investigate the effects of generalised trust and happiness on all-cause and cause-specific mortality. The distinction between different causes of death (i.e. cardiovascular vs. cancer-related mortality) allowed us to assess if psychosocial mechanisms could account for associations between generalised trust, happiness and mortality. The study sample was derived from US General Social Survey data from 1978 to 2010 (response rates ranged from 70 to 82 per cent), and combined with death records from the National Death Index. The analytical sample comprised 23,933 individuals with 5382 validated d...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Authors: Lin WC, Tsai JP, Lai YH, Lin YL, Kuo CH, Wang CH, Hsu BG Abstract Osteoprotegerin (OPG) is a potential biomarker of cardiovascular disease complications and severity. Peripheral arterial disease (PAD) is associated with an increased risk of death in patients on peritoneal dialysis (PD). Therefore, this study aimed to evaluate the relationship between serum OPG levels and PAD by measuring the ankle-brachial index (ABI) of patients on PD. A commercial enzyme-linked immunosorbent assay kit was used to measure OPG values. Left or right ABI values of
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Authors: Feng X, Zhang M, Meng J, Wang Y, Liu Y, Liang C, Fan S Abstract We aimed to investigate the potential mechanisms of progression and identify novelprognosis-related biomarkers for papillary renal cell carcinoma (PRCC) patients. The relateddata were derived from The Cancer Genome Atlas (TCGA), and then, analyzed by Weightedgene co-expression network analysis (WGCNA). The correlation between each module andthe clinical traits were analyzed by Pearson's correlation analysis. Pathway analysis wasconducted to reveal potential mechanisms. Hub genes within each module were screenedby intra-module analysis, and vis...
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research
This study has important implications for the future investigations of prevention of periprosthetic infection. The nomogram model identifies high-risk patients for whom attached prophylaxis measures are required. Future studies regarding reduction of incidence of periprosthetic infection should pay close attention to these high-risk patients.Level of evidenceIV, retrospective, cohort study.
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
Publication date: Available online 18 January 2020Source: Gynecologic Oncology ReportsAuthor(s): Bijan Morshedi, Kari RingAbstractPemphigus is a group of autoimmune intraepidermal blistering diseases caused by immunoglobulins directed against keratinocyte cell surface components. In this case report, we identify a non-classical paraneoplastic pemphigus (PNP) foliaceous related to an undifferentiated uterine sarcoma.The patient is a 54-year-old female with a past medical history of arthritis who presented with worsening fatigue in November 2017 and an itchy, blistering, erythematous annular plaque that first appeared on her...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
We report a unique case of a 60-year-old woman developing endometrial cancer in a uterine deposit 18 years after she had undergone laparoscopic subtotal hysterectomy with morcellation for benign pathology. She had used unopposed estrogen as menopausal hormone therapy. She presented with a pelvic mass that was causing pressure symptoms. On imaging, the mass had an enhancing vascular nodular component and appeared to abut normal ovaries and the residual cervix. She proceeded to laparotomy, where a 12 cm pelvic mass was found morbidly adherent to the bladder anteriorly and to the cervical stump. The pelvic mass was excise...
Source: Case Reports in Womens Health - Category: OBGYN Source Type: research
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Source: Journal of Investigative Surgery - Category: Surgery Tags: J Invest Surg Source Type: research
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Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
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