Oromandibular Dystonia Causing Recurrent Mandibular Open Lock in Two Adolescents Managed with Botulinum Toxin

Source: Journal of Dentistry for Children - Category: Dentistry Authors: Tags: Case Reports Source Type: research

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Spasmodic dysphonia (SD) is an isolated focal dystonia characterized by laryngeal spasms during voluntary voice production. Environmental factors have been assumed to play a role in SD pathophysiology; however, the exact extrinsic risk factors and their association with neural alterations remain unknown.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
We report the case of a 21-year-old male with a history of mental illness that presented with selective mutism, disorganized speech, thought process and behavior, and auditory hallucinations who accidentally received 624 mg Paliperidone Palmitate intramuscularly with no reported side effects after 2 weeks of monitoring and observation. Paliperidone is a D2, 5HT2A receptor antagonist with additional antagonist activity at α-1 and α-2, H-1 receptor sites, and four metabolic pathways identified for its metabolism. Studies have reported adverse effects such as acute dystonia, acute renal failure, and cardiov...
Source: Case Reports in Psychiatry - Category: Psychiatry Tags: Case Rep Psychiatry Source Type: research
ConclusionThese findings collectively suggested that initial symptoms influenced phenotypes in SCA3 and that neurodegeneration in different parts of brain may induce different disease severity in SCA3.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
Publication date: Available online 21 May 2019Source: Brain StimulationAuthor(s): Hu Liang Low, Sian K. Alexander, Anjum Misbahuddin, Godfrey T. Gillett
Source: Brain Stimulation - Category: Neurology Source Type: research
Conclusions: All patients reported a communication complaint, attested by the DIP scores, despite the fact that not all patients, notably PD, ataxic, and PSP patients, had an intelligibility deficit. The DIP should be used in clinical practice to contribute to a holistic evaluation and management of functional communication in patients with dysarthria.Neurodegener Dis
Source: Neurodegenerative Diseases - Category: Neurology Source Type: research
Deep brain stimulation (DBS) has become the treatment of choice for advanced stages of Parkinson's disease, medically intractable essential tremor, and complicated segmental and generalized dystonia. In addition to accurate electrode placement in the target area, effective programming of DBS devices is considered the most important factor for the individual outcome after DBS. Programming of the implanted pulse generator (IPG) is the only modifiable factor once DBS leads have been implanted and it becomes even more relevant in cases in which the electrodes are located at the border of the intended target structure and when ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Wilson ’s disease (WD) is an autosomal recessive disorder of copper metabolism associated with ATP7B gene mutations. In this condition, copper accumulates in various tissues especially the brain, and liver. The resulting cellular dysfunction commonly manifests as ataxia, tremor, dystonia and parkinsonism . Whilst copper chelation therapies, including trientene and penicillamine, are well-established disease-modifying treatments, up to 50% of patients have persistent neurological symptoms despite optimal non-surgical therapy [1].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research
CONCLUSIONS: All patients reported a communication complaint, attested by the DIP scores, despite the fact that not all patients, notably PD, ataxic, and PSP patients, had an intelligibility deficit. The DIP should be used in clinical practice to contribute to a holistic evaluation and management of functional communication in patients with dysarthria. PMID: 31112944 [PubMed - as supplied by publisher]
Source: Neuro-Degenerative Diseases - Category: Neurology Authors: Tags: Neurodegener Dis Source Type: research
Wilson's disease (WD) is an autosomal recessive disorder of copper metabolism associated with ATP7B gene mutations. In this condition, copper accumulates in various tissues especially the brain, and liver. The resulting cellular dysfunction commonly manifests as ataxia, tremor, dystonia and parkinsonism. Whilst copper chelation therapies, including trientene and penicillamine, are well-established disease-modifying treatments, up to 50% of patients have persistent neurological symptoms despite optimal non-surgical therapy [1].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research
Source: Journal of Neurology - Category: Neurology Source Type: research
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