Oromandibular Dystonia Causing Recurrent Mandibular Open Lock in Two Adolescents Managed with Botulinum Toxin

Source: Journal of Dentistry for Children - Category: Dentistry Authors: Tags: Case Reports Source Type: research

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ConclusionsAL 1064  mg q8wk provided continuous exposure to aripiprazole throughout the 8-week dosing interval and had a safety profile consistent with the 4- and 6-week regimens. These findings were used to support FDA approval of the 1064-mg dose administered every 2 months.RegistrationClinicaltrials.gov: NCT02320032
Source: CNS Drugs - Category: Neurology Source Type: research
Abstract INTRODUCTION: Cervical dystonia is a form of focal dystonia characterised by tilting and turning of the head and neck. This can cause significant disability in affected patients. Botulinum toxin injections are the mainstay of therapy. However, approximately 30% of patients discontinue treatment. CLINICAL REFLECTIONS: Tyślerowicz et al. have provided a comprehensive review of the factors contributing to treatment failure. Such factors include appropriate identification of dystonia patterns, accurate injection of muscles, and addressing non-motor features of cervical dystonia. CLINICAL IMPLICATIO...
Source: Neurologia i Neurochirurgia Polska - Category: Neurology Authors: Tags: Neurol Neurochir Pol Source Type: research
Publication date: Available online 30 June 2020Source: Neurología (English Edition)Author(s): Í. Isern de Val, J. Gazulla
Source: Neurologia - Category: Neurology Source Type: research
Task-specific dystonia (TSD) is an isolated focal dystonia which is displayed only during the performance of a particular skilled motor task. TSD encompasses loss of motor control confined to a specific motor skill. In some even the thought of performing the concerned motor task initiates a dystonic posturing. Pain is usually not a dominant feature of TSD and fluctuations in symptoms are common though remissions are rare. The most common types of TSD are writer's cramp, musicians' dystonia, and dystonia in upper limbs related to sports and occupation.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Correspondence Source Type: research
Conclusions: This review identified some of the common neurological impairments across diseases and showed that technology can be beneficial for neurological patients by helping them with everyday living. The review also found that different aspects such as personal aspects of the intended users (e.g., impairments) and physical and environmental context of the task play an essential role in the usefulness of the technology.Implications for rehabilitationNeurological diseases are globally the leading cause of disability, whereby there is a great need for rehabilitation of neurological impairments.Assistive technology can co...
Source: Disability and Rehabilitation. Assistive Technology. - Category: Rehabilitation Authors: Tags: Disabil Rehabil Assist Technol Source Type: research
Publication date: Available online 30 June 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Stefanie Perl, Franziska Richter, Angelika Richter
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
Multiple studies implicate heterozygous GBA mutations as a major genetic risk factor for Parkinson's disease (PD); however, the frequency of mutations has never been examined in PD patients from the Irish population. We prospectively recruited 314 unrelated Irish PD patients (UK Brain Bank Criteria) and 96 Irish healthy controls (without any signs or family history of parkinsonism) attending. The Dublin Neurological Institute (DNI). Complete exon GBA Sanger sequencing analysis with flanking intronic regions was performed. The GBA carrier frequency was 8.3% in PD and 3.1% in controls. We identified a number of potentially p...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ATP1A3-related dystonia is a clinical syndrome with high genetic heterogeneity. Rapid-Onset Dystonia Parkinsonism (RDP), Alternating Hemiplegia of Childhood (AHC) and CAPOS (Cerebellar ataxia, Areflexia, Pes cavus, Optic atrophy, and Sensorineural hearing loss) syndrome have been reported to be related to ATP1A3 gene mutations [1]. Here, we describe two pedigrees carring two de-nove ATP1A3 variants with RDP-CAPOS overlapping phenotype or continuous hemidystonia.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
The gene encoding myelin-associated glycoprotein (MAG) has been implicated in autosomal-recessive spastic paraplegia type 75. To date, only four families with biallelic missense variants in MAG have been reported. The genotypic and phenotypic spectrum of MAG-associated disease awaits further elucidation.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Short communication Source Type: research
AbstractOromandibular dystonia (OMD) is a clinically and etiologically heterogeneous form of focal dystonia with variable social and functional implications. The results of pharmacological treatment and botulinum toxin infiltrations are often unsatisfactory. We performed a systematic review on the effects of oral and dental appliances in patients with OMD. Most of the reports in the literature are single subject descriptions or small case series with a considerable variability in the type of dystonia, the type of evaluated appliances and in the outcome measures. Only one report included a large group of unselected patients...
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
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