Immune Checkpoint Molecules in Reproductive Immunology

Immune Checkpoint Molecules in Reproductive Immunology Eva Miko1,2*, Matyas Meggyes1,2, Katalin Doba1, Aliz Barakonyi1,2 and Laszlo Szereday1,2 1Department of Medical Microbiology and Immunology, Medical School, University of Pécs, Pécs, Hungary 2Janos Szentagothai Research Centre, Pécs, Hungary Immune checkpoint molecules, like CTLA-4, TIM-3, PD-1, are negative regulators of immune responses to avoid immune injury. Checkpoint regulators are thought to actively participate in the immune defense of infections, prevention of autoimmunity, transplantation, and tumor immune evasion. Maternal-fetal immunotolerance represents a real immunological challenge for the immune system of the mother: beside acceptance of the semiallogeneic fetus, the maternal immune system has to be prepared for immune defense mostly against infections. In this particular situation, the role of immune checkpoint molecules could be of special interest. In this review, we describe current knowledge on the role of immune checkpoint molecules in reproductive immunology. Introduction The activation of the immune system to eliminate harmful agents is usually followed by tissue damage at the site of the exposure. In order to keep this side effect of the immune response limited and localized, efficient immunoactivation of immune cells requires multiple incoming signals. Beside antigen recognition, co-stimulatory, survival, and proliferative signals, even environmental factors...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

Related Links:

Publication date: Available online 28 February 2020Source: Veterinary ParasitologyAuthor(s): Zoltán Széll, Árpád Bacsadi, Levente Szeredi, Csaba Nemes, Brigitta Fézer, Erika Bakcsa, Hédi Kalla, Zoltán Tolnai, Tamás Sréter
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
Authors: Berenbaum F, Walker C Abstract Globally, osteoarthritis (OA) is the most prevalent arthritic condition in those aged over 60 years. OA has a high impact on patient disability and is associated with a significant economic burden. Pain is the most common first sign of disease and the leading cause of disability. Data demonstrating the increasing global prevalence of OA, together with a greater understanding of the burden of the disease, have led to a reassessment of the seriousness of OA and calls for the designation of OA as a serious disease in line with the diseases impact on comorbidity, disability,...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Conclusion: CAM practice and herb consumption were highly prevalent among patients with CKD. Patients inadequately inform the primary physicians about their CAM practices. Therefore, healthcare providers are encouraged to inquire about these practices. PMID: 32099440 [PubMed]
Source: International Journal of Nephrology and Renovascular Disease - Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research
Authors: Shabataev V, Saadat SH, Elterman DS Abstract The two major long-term concerns associated with different options for the management of prostate cancer, (including surgery, radiotherapy, brachytherapy, cryotherapy, HIFU, etc.) include difficulties with lower urinary tract symptoms (LUTS) and/or erectile dysfunction. LUTS can be in the form of stress urinary incontinence (SUI), urge urinary incontinence (UUI), frequency/urgency, and/or voiding difficulties. While surgery is mostly associated with SUI and radiation mostly results in UUI, there can be an overlap. Incontinence rates after cryotherapy and high in...
Source: Canadian Journal of Urology - Category: Urology & Nephrology Tags: Can J Urol Source Type: research
Authors: Magee DE, Singal RK Abstract Our objective is to provide an up-to-date summary of current literature on the indications for androgen deprivation therapy (ADT), ways in which ADT is used, and the main side effects associated with its use. MEDLINE (Pubmed) was searched for relevant papers published from database inception to May 1, 2019 for studies evaluating the use of ADT and its associated adverse events. ADT is a mainstay in the treatment of prostate cancer and is used throughout the disease course. While predominantly used in the metastatic setting, ADT has a role in the treatment of localized disease a...
Source: Canadian Journal of Urology - Category: Urology & Nephrology Tags: Can J Urol Source Type: research
Authors: Law KW, Nguyen DD, Barkin J, Zorn KC Abstract Prostate cancer screening remains highly controversial in medicine. The College of Family Physicians of Canada currently endorses positions that recommend against prostate-specific antigen (PSA) screening in men of all ages, while the Canadian Urological Association recommends shared and informed decision making for PSA screening in men 50-70 years old. Unfortunately, these opposing stances have left Family Physicians responsible for interpreting the appropriate course of action for their patients. Recent studies demonstrating an increase in incidence of metast...
Source: Canadian Journal of Urology - Category: Urology & Nephrology Tags: Can J Urol Source Type: research
This article is categorized under: Biological Mechanisms> Metabolism Translational, Genomic, and Systems Medicine> Translational Medicine Biological Mechanisms> Cell Signaling
Source: Wiley Interdisciplinary Reviews: Systems Biology and Medicine - Category: Biomedical Science Authors: Tags: ADVANCED REVIEW Source Type: research
[Premium Times] We are trying our best to provide services for international students. The Chinese government cares about the life and health of foreign students, just as we care about those of our own children. Leading local officials have either visited foreign students in person or spoken to them through video links. For example, the Party Secretary of Jiangxi Province visited the more than 500 international students in Nanchang University to offer his support.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Contributors : Lu Xin ; Liu GuoqiangSeries Type : Expression profiling by arrayOrganism : Mus musculusMyeloid derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells with differentiation program partially blocked in pathological conditions such as cancer. Through inhibition of T cells especially cytotoxic T lymphocytes (CTLs), MDSCs play important tumor-promoting roles and maintain a state of immunological anergy and toleranceWe used microarrays to profile gene expression of Gr-MDSC and identified differentially altered genes under different drug treatment.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
In this study, a versatile reduced graphene oxide (rGO) based drug delivery system (DDS) was developed for... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
More News: Academia | Adenoviruses | Allergy & Immunology | Arthritis | Asthma | Autoimmune Disease | Biology | Bone Graft | Burns | Cancer | Cancer & Oncology | Cancer of the Uterus | Cardiology | China Health | Clinical Trials | Endometrial Cancer | Environmental Health | Finland Health | Gastroenterology | Genetics | Gestational Trophoblastic Tumor | Grants | Heart | Heart Transplant | Hungary Health | Immunotherapy | India Health | Lessons | Liver | Liver Transplant | Men | Microbiology | Miscarriage | Myelodysplastic Syndrome | Perinatology & Neonatology | PET Scan | Pre-eclampsia | Pregnancy | Reproduction Medicine | Rheumatoid Arthritis | Rheumatology | Study | Thyroid | Thyroid Cancer | Transplants | Urology & Nephrology | Women