Hydrogen sulfide protects H9c2 cardiomyoblasts against H2O2-induced apoptosis.
In this study, we investigated the cytoprotective effect of H2S against H2O2-induced apoptosis in cardiomyocytes. H9c2 rat cardiomyoblasts were treated with H2S (100 μM) 24 h before challenging with H2O2 (100 μM). Apoptosis was then assessed by annexin V and PI, and mitochondrial membrane potential was measured using a fluorescent probe, JC-1. Our results revealed that H2S improved cell viability, reduced the apoptotic rate, and preserved mitochondrial membrane potential. An increased Bcl-2 to Bax ratio was also seen in myocytes treated with H2S after H2O2-induced stress. Our findings indicated a therapeutic potential for H2S in preventing myocyte death following ischemia/reperfusion.
PMID: 30994729 [PubMed - in process]
Source: Braz J Med Biol Res - Category: Research Authors: Zhang YE, Huang GQ, Wu B, Lin XD, Yang WZ, Ke ZY, Liu J Tags: Braz J Med Biol Res Source Type: research
More News: Cardiology | Cardiovascular | Chemistry | Heart | Mitochondrial Disease | Research | Study