Differential impairment patterns of the corticospinal tract segments in alcohol dependence.

CONCLUSIONS: These findings suggest that CST impairments may vary with the fibre arrangement patterns of its segments in alcohol dependence. Keypoints We reconstructed the CST using tractography based on DTI data and divided the CST into different segments in order to explore more detailed micro-structural integrity changes in alcoholisms. Alcohol-dependent patients showed decreased RD and MD for the bilateral inferior segments of the CSTs. The left-superior segment exhibited decreased FA and increased RD while the right one exhibited increased AD and MD. These findings suggest that CST impairments may vary with the fiber arrangement patterns of its segments in alcohol dependence. In future work, more elaborate segmentation schemes and lager samples should be used to test the reproducibility of our findings.
PMID: 30987473 [PubMed - as supplied by publisher]

Source: International Journal of Psychiatry in Clinical Practice - April 18, 2019 Category: Psychiatry Tags: Int J Psychiatry Clin Pract Source Type: research