Advances in Cardiovascular Disease Lipid Research Can Provide Novel Insights Into Mycobacterial Pathogenesis

Conclusions Decrease in cholesterol efflux, increase in uptake, and excess esterification of cholesterol compounded by the action of lipid peroxidation products generated by inflammatory processes contribute to foam cell formation in atherosclerosis. Since these are critical events in the pathogenesis of atherosclerosis, they have been extensively studied. On the contrary, although a role for host lipid metabolism in mycobacterial pathogenesis has been established, research in the different components that contribute to the alteration in host lipid metabolism and cholesterol homeostasis is still in the nascent stages. The specific cause for reactivation of mycobacterial disease from a controlled state in an infected host is still a critical question that remains inconclusive. It is speculated that the reversible lipid accumulation in foamy macrophages could be a possible phenomenon that is associated with disease reactivation (Caire-Brändli et al., 2014). Researchers attempting to decipher these loopholes in TB pathogenesis specifically targeting the host lipid pathway with the aim of developing novel therapeutics and vaccination strategies would be better served by utilizing the plethora of resources available in this area in the cardiovascular field (Kurth et al., 2004; Han et al., 2017; Rodriguez et al., 2017). The potential for PPAR regulators of airway inflammation as potential therapeutic targets for asthma and lung diseases (Standiford et al., 2005; Banno et a...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research