Advances in Cardiovascular Disease Lipid Research Can Provide Novel Insights Into Mycobacterial Pathogenesis

Conclusions Decrease in cholesterol efflux, increase in uptake, and excess esterification of cholesterol compounded by the action of lipid peroxidation products generated by inflammatory processes contribute to foam cell formation in atherosclerosis. Since these are critical events in the pathogenesis of atherosclerosis, they have been extensively studied. On the contrary, although a role for host lipid metabolism in mycobacterial pathogenesis has been established, research in the different components that contribute to the alteration in host lipid metabolism and cholesterol homeostasis is still in the nascent stages. The specific cause for reactivation of mycobacterial disease from a controlled state in an infected host is still a critical question that remains inconclusive. It is speculated that the reversible lipid accumulation in foamy macrophages could be a possible phenomenon that is associated with disease reactivation (Caire-Brändli et al., 2014). Researchers attempting to decipher these loopholes in TB pathogenesis specifically targeting the host lipid pathway with the aim of developing novel therapeutics and vaccination strategies would be better served by utilizing the plethora of resources available in this area in the cardiovascular field (Kurth et al., 2004; Han et al., 2017; Rodriguez et al., 2017). The potential for PPAR regulators of airway inflammation as potential therapeutic targets for asthma and lung diseases (Standiford et al., 2005; Banno et al.,...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research

Related Links:

AbstractAplastic anemia (AA) has been reported to be associated with inflammatory bowel disease (IBD), but mostly with ulcerative colitis (UC). Little is known about the associations between AA and Crohn ’s disease (CD). We aim to determine the portraits of patients with AA-CD. Among a total of 657 patients with CD registered in Xijing Hospital of Digestive Diseases IBD center from January 2008 to October 2018, the patients diagnosed with concurrent AA were reviewed. Clinical presentation, medical history, endoscopic features, response to treatment, and prognosis in this set of patients were collected. Six male patie...
Source: Annals of Hematology - Category: Hematology Source Type: research
Normally, each month when new issues of journals are opened or scanned online, there can be an element of excitement together with an element of trepidation. The latter can stem from complicated tables concerning obscure genes that govern inflammatory pathways that interact with bacteria, tedious immunologic data, and metabolic novelties that boggle the mind. However, in this issue of Gastrointestinal Endoscopy, Overwater et  al1 have provided us with a breath of fresh air.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research
Gastric cancer remains one of the most common causes of cancer deaths worldwide. The best current option for reducing gastric cancer deaths is Helicobacter pylori eradication combined with risk assessment and surveillance programs for those deemed to be at high risk for gastric cancer so as to identify lesions at a stage amenable to curative therapy. In this issue, Nam et  al1 report a retrospective study of Helicobacter pylori eradication on gastric cancer incidence among 10,328 Korean adults undergoing health checkups including an H pylori test-and-treat program.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research
We read with great interest the comment by Dr Li and colleagues1 referring to our study on endoscopic full-thickness resection (EFTR) for early colorectal cancer.2 We would like to thank the editors for the opportunity to reply.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Gastric cancer remains one of the most common cancers worldwide and is the third leading cause of cancer-related mortality, trailing only lung and colon cancer.1 Given its historically low survival rates, early detection and resection is the most effective strategy to improve prognosis. Endoscopic submucosal dissection (ESD), a technique developed in Japan, enables en bloc resection of early gastric cancer (EGC) and can be curative for selected lesions, depending on the histologic features, size, and tumor depth.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research
We read with interest the article by Kuellmer et  al1 evaluating endoscopic full-thickness resection (EFTR) for early colorectal cancer. The authors found that EFTR for early colorectal cancer was feasible and safe. Because their findings are important to current practice, several questions deserve attention.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
We have read with great interest the study by Januszewicz et  al1 describing the concept of endoscopist biopsy rate (EBR) as a potential quality indicator for routine diagnostic outpatient EGD. The authors found a significant variability in EBR among 26 endoscopists and an association between higher EBR, a higher detection of gastric precancerous conditions, and a lower risk of missed gastric cancers.1
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
This study uses interviews (qualitative) to collect data from women technology librarians who work in an academic library within the United States.Research limitations/implicationsThe generalizability of the findings is due to the sample consisting of only academic librarians within the United States. The methodology also has limitations since interviews are not a perfect methodology and rely on self-reported descriptions and experiences; thus, may be susceptible to perceptional biases. The findings from the research also rely only on the gender variable while ignoring other variables that affect an individual's experience...
Source: The Journal of Academic Librarianship - Category: Databases & Libraries Source Type: research
ConclusionThese findings suggested that C. inerme leaves have potent antidiabetic and anti-oxidant activities. The results provide reliable scientific base, which is the premise for further research and development of CILE as supplements.
Source: Chinese Herbal Medicines - Category: Complementary Medicine Source Type: research
AbstractPurposeFatigue is a common and distressing symptom in cancer patients which negatively affects patients ’ daily functioning and health-related quality of life. The aim of this study was to assess multidimensional fatigue in patients with brain metastases (BM) before, and after Gamma Knife radiosurgery (GKRS).MethodsPatients with BM, an expected survival  >  3 months, and a Karnofsky Performance Status ≥ 70 and 104 Dutch non-cancer controls were recruited. The Multidimensional Fatigue Inventory (MFI), measuring general fatigue, physical fatigue, mental fatigue, reduced ac...
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
More News: Allergy & Immunology | Antidoxidants | Arthritis | Asthma | Autoimmune Disease | Biology | Cancer | Cancer & Oncology | Cancer Vaccines | Cardiology | Cardiovascular | Cholesterol | Crohn's Disease | Environmental Health | Epidemiology | Fish | Genetics | Grants | Heart | Hormones | Infectious Diseases | Iron | Leprosy | Liver | Men | Menopause | Microbiology | Molecular Biology | Nutrition | Pathology | PET Scan | Rheumatology | Science | Skin | Statin Therapy | Study | Tuberculosis | Urology & Nephrology | USA Health | Vaccines | Veterinary Vaccinations | Vitamin D | Vitamin D Deficiency | Vitamins | Washington University | Women