Antimicrobial Activity of Lactobacillus Species Against Carbapenem-Resistant Enterobacteriaceae

Conclusion: Some Lactobacillus strains exhibit anti-CRE activity, which suggests potential applications for controlling or preventing CRE colonization or infection. Introduction Although Enterobacteriaceae are normal flora of the human intestinal system, they are also common pathogens causing human infections in the setting of both community-acquired and healthcare-associated infections (Hsueh et al., 2010; Toh et al., 2012; Lai et al., 2014; Jean et al., 2016). In this era of widespread antibiotic resistance, Enterobacteriaceae are no exception. Recently, the emergence of carbapenem-resistant Enterobacteriaceae (CRE) has become a more critical issue due to the limited therapeutic options available for these pathogens and the significant morbidity and mortality associated with CRE infections (Tang et al., 2016a; Rodriguez-Bano et al., 2018). Therefore, there is an urgent need for new treatments for these critical CRE-associated conditions. Lactobacillus is one of a number of probiotics considered to be biological therapeutics and host immune-modulating biologicals that are generally recognized as safe (GRAS). Recent studies demonstrated several antimicrobial mechanisms of Lactobacillus such as nutrient competition, production of inhibitory compounds, immune-stimulation and competition for binding sites. In addition, Lactobacillus can produce lactic acid, acetic acid, formic acid and other acids to reduce intestinal pH, which may be the most important mechanism. These...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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This study aimed to evaluate the effects of a diet supplemented with beta-glucan from yeast, Saccharomyces cerevisiae (Sc-βG), on the stress response of Oreochromis mossambicus (Tilapia) to ammonia. Fish were divided into four groups, including a control fed a basal diet and three experimental groups fed diets supplemented with Sc-βG at 2, 5 and 10 mg/g respectively. After 8 weeks, experimental groups were exposed to ammonia at 100 mg L−1 for 1 week. Growth was measured after the 8-week feeding trial and serum, mucus, and liver tissue were sampled before and after the ammonia challenge. Compared with ...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
ConclusionThese data suggest that a combined 2-h infusion with a higher dosage of meropenem, including a loading dose, may be successful to achieve effective PK parameters.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 10 December 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Yuxue Cao, Mahdi Naseri, Yan He, Chun Xu, Laurence J. Walsh, Zyta M. ZioraAbstractBiofilms can be produced by multiple species or by a single strain of bacteria. The biofilm state enhances the resistance of the resident microorganisms to antimicrobial agents by producing extracellular polymeric substances. Typically, antibiotics are used to stop the growth of bacteria, but emerging resistance has limited their effectiveness. Bacteria in biofilms are less susceptible to antibiotics compared with their free-floatin...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 9 December 2019Source: Journal of ColoproctologyAuthor(s): Seyedeh Elham Norollahi, Seyed Mohammad Taghi Hamidian, Zeynab Khazaee Kohpar, Rezvan Azadi, Pooya Rostami, Sogand Vahidi, Sahar Ghazanfari, Farnaz Azar Shabe, Roya Khaksar, Ali Akbar SamadaniAbstractColorectal cancer is one of the most important malignancies in the classification of gastrointestinal cancers. One of the predisposing factors at molecular level for this cancer is via WNT signaling which is associated with the vast numbers of different genes. Thus, in this study, we aimed to investigate whether Adenomatous Polyposis ...
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
Publication date: Available online 10 December 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Aabha Nagral, Moinak S. Sarma, John Matthai, Prashanth L. Kukkle, Harshad Devarbhavi, Sanjib Sinha, Seema Alam, Ashish Bavdekar, Radha K. Dhiman, Chundamannil E. Eapen, Vinay Goyal, Neelam Mohan, Rukmini M. Kandadai, Malathi Sathiyasekaran, Ujjal Poddar, Anupam Sibal, Srinivas Sankaranarayanan, Anshu Srivastava, Baburam R. Thapa, Pettarusp M. Wadia
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
ConclusionThe MiRa scale is the only aesthetic analysis scale validated in the literature for nasal dysmorphoses. The combined use of two sets of translation recommendations, with a five-step translation-back-translation process, made it possible to obtain a French version perfectly in line with the original. This version is usable by French-speakers.
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases - Category: ENT & OMF Source Type: research
Publication date: Available online 25 September 2019Source: Canadian Journal of DiabetesAuthor(s): Tyler B. Dubois, Scot H. Simpson, Dean T. EurichAbstractObjectivesOur aim in this study was to determine whether differences exist in time to treatment intensification in newly treated type 2 diabetes patients in Canada and the United States (US).MethodsTwo separate retrospective cohorts of diabetes patients were used from Canada and the US. Time to treatment intensification (i.e. addition of a second antihyperglycemic agent after initial metformin use) was determined using multivariate Cox proportional hazard models.ResultsA...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Metabolic Syndrome and Related Disorders, Ahead of Print.
Source: Metabolic Syndrome and Related Disorders - Category: Endocrinology Authors: Source Type: research
In this study, we established the first liquid chromatography-tandem mass spectrometry (LC–MS/MS) method for the simultaneous quantification of LZD and its main metabolites in human serum. Proteins in serum samples were precipitated with acetonitrile containing a deuterated internal standard. Chromatographic separation of analytes was performed with Waters X-bridge column (C18, 150 × 4.6 mm, 3.5 μm) at 25 °C and subjected to mass analysis using positive electro-spray ionization. The mobile phase A was water with 0.1% formic acid, and mobile phase B was acetonitrile with 0.1% formic acid at a fl...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
Conclusion: FV application every three months can be recommended to prevent caries lesions on the erupting first permanent molars of high-risk populations.
Source: Oral health and Preventive dentistry - Category: Dentistry Source Type: research
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