Antimicrobial Activity of Lactobacillus Species Against Carbapenem-Resistant Enterobacteriaceae

Conclusion: Some Lactobacillus strains exhibit anti-CRE activity, which suggests potential applications for controlling or preventing CRE colonization or infection. Introduction Although Enterobacteriaceae are normal flora of the human intestinal system, they are also common pathogens causing human infections in the setting of both community-acquired and healthcare-associated infections (Hsueh et al., 2010; Toh et al., 2012; Lai et al., 2014; Jean et al., 2016). In this era of widespread antibiotic resistance, Enterobacteriaceae are no exception. Recently, the emergence of carbapenem-resistant Enterobacteriaceae (CRE) has become a more critical issue due to the limited therapeutic options available for these pathogens and the significant morbidity and mortality associated with CRE infections (Tang et al., 2016a; Rodriguez-Bano et al., 2018). Therefore, there is an urgent need for new treatments for these critical CRE-associated conditions. Lactobacillus is one of a number of probiotics considered to be biological therapeutics and host immune-modulating biologicals that are generally recognized as safe (GRAS). Recent studies demonstrated several antimicrobial mechanisms of Lactobacillus such as nutrient competition, production of inhibitory compounds, immune-stimulation and competition for binding sites. In addition, Lactobacillus can produce lactic acid, acetic acid, formic acid and other acids to reduce intestinal pH, which may be the most important mechanism. These...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

Related Links:

From both a public health and an economic perspective, Britain performed poorly during the Covid-19 crisis in comparison with similar countries. When put to the test, many of Britain's core systems were revealed to be incapable of withstanding extra stress and demand. Written in partnership with Local Trust, this paper intends to start a conversation about how the country can move towards resilience for a more prepared and better future. It identifies five pillars that need to form the centrepiece of any approach: economic resilience; public sector resilience; community resilience; environmental resilience; and workforce resilience.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
India has recorded nearly 87,000 new coronavirus infections as it edges closer to the United States in having the most cases in the world
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
New Zealand says it will ease its virus measures. Lockdowns return as Europe faces a second wave.
Source: NYT Health - Category: Consumer Health News Tags: Coronavirus (2019-nCoV) Source Type: news
Authors: Polistina GE, Simioli F, Imitazione P, Lanza M, Annunziata A, Fiorentino G Abstract The coronavirus disease 2019 (COVID-19) is a recent pandemic that affected more than 5 million people worldwide. Chest high resolution computed tomography (HRCT) is an essential tool in diagnosis and management of the disease. Pulmonary parenchymal opacity is a typical sign of the disease, but not the only one. Pneumothorax, pneumomediastinum, bronchiectasis and cysts are probably underrated complications of COVID-19 that can worsen prognosis, in terms of prolonged hospitalization and need of oxygen therapy. In our single c...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
Conclusion: The results of this review indicate that most osteopathic medical schools are at the early stages of EPA implementation, with emphasis varying by program year in terms of the specific EPAs addressed. Many schools appear engaged in curricular change efforts that will support the advancement of EPA use within their institutions. Faculty development was identified as a continued critical need for a majority of institutions. PMID: 32946547 [PubMed - as supplied by publisher]
Source: Journal of the American Osteopathic Association - Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research
The robotic technology will be used to conduct procedures such as hernia repair surgeries, prostatectomies and hysterectomies.
Source: mobihealthnews - Category: Information Technology Source Type: news
Authors: Lora CV, Nastro M, Vay C, Famiglietti A, Rodríguez CH Abstract A rapid colorimetric method, the Andrade screening antimicrobial test, was compared with the E-test method to detect ceftazidime/avibactam (CZA) resistance in carbapenem resistant Enterobacterales clinical isolates. A 106 non-duplicated isolates (86 susceptible and 20 resistant to CZA) were chosen for validation. The sensitivity and specificity were 100%. This method investigates CZA resistance regardless of the resistance mechanism involved. It represents an economical and easy technique that can be applied to routine microbiology labor...
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
Follicular dendritic cell sarcoma (FDCS) is a rare sarcoma, which commonly presents as a slow-growing, painless mass. There are only a few hundred reported FDCS cases, and the role for adjuvant chemo- or radiation therapy has not been established. Choosing an appropriate therapy in disseminated disease can therefore be challenging. A 26-year-old patient with FDCS was admitted with dyspnea, fever, and night sweats. He was found to have a large right hemothorax with compressive atelectasis on initial imaging. CT of the chest revealed multiple bilateral lung and pleural nodules with associated bilateral hilar adenopathy, a hy...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 9 September 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Mariana Albano, Wim Alexander Fleischmann, Kerryl E. Greenwood-Quaintance, Robin Patel
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
CONCLUSION: Our results showed that the evaluation of the disease process from 3 days to nine days after a 10 min contact of acid to the colon is a suitable model that mimics the histological features of the disease. PMID: 32945217 [PubMed - as supplied by publisher]
Source: Journal of Investigative Surgery - Category: Surgery Tags: J Invest Surg Source Type: research
More News: Academia | Acetic Acid | Acidophilus | Antimicrobial Resistance | Bactrim | Bile | Biotechnology | Chemotherapy | Chia | Clindamycin | Clostridium Difficile | Databases & Libraries | Diets | Doxycycline | Dysentery | Economics | Enterococcus | Environmental Health | Epidemiology | Erythromycin | Food Science | France Health | Gastroenteritis | Gastroenterology | Genetics | Intensive Care | Iran Health | Italy Health | Laboratory Medicine | Lactobacillus Acidophilus | Linezolid | Microbiology | Middle East Health | Molecular Biology | Multidrug Resistance | Nutrition | Organic | Pneumonia | Probiotics | Reproduction Medicine | Research | Science | Sodium Chloride | Staphylococcus Aureus | Statistics | Study | Sulfamethoxazole | Taiwan Health | Trimethoprim | UK Health | Urinary Tract Infections | USA Health | Zyvox