Gegen Qinlian Decoction Treats Diarrhea in Piglets by Modulating Gut Microbiota and Short-Chain Fatty Acids

In conclusion, our study might provide evidence that GQD treats diarrhea maybe involved in modulating gut microbiota and increasing SCFA levels. Introduction Diarrheal diseases cause approximately 1.7 billion new infections and 0.76 million deaths in children of under 5 years of age annually and are thus the second most common cause of mortality in young children in developing countries (Kotloff et al., 2012, 2013). Outbreaks of such diseases are usually related to infection by common causative agents, mainly rotavirus, Salmonella enterica, and diarrheagenic Escherichia coli (Hodges and Gill, 2010; Kolenda et al., 2015). Recent studies have suggested that diarrhea is strongly related to the dysbiosis of gut microbiota (Shrivastava et al., 2017; The et al., 2017). Gut microbiota mainly colonize the large intestine. Their capacity to help colonic fermentation, stimulation of the immune system, and colonization resistance against diarrheal pathogens underlie their importance to human health (Baumler and Sperandio, 2016; Zhang et al., 2017). However, childhood colonization resistance of gut microbiota is weak due to the immaturity of intestinal micro-ecology. The perturbations of the gut microbial community by various etiological agents is one of the main pathogeneses during the early phase of diarrheal infection (Vogt and Finlay, 2017); pathogens could induce diarrhea by transient reversals of the enteric levels of Bacteroides and Prevotella (David et al., 2015). Prior ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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Authors: Park MG, Cho MC, Cho SY, Lee JW Abstract OBJECTIVES: To compare the antibiotic susceptibility of Escherichia coli (E. coli) between community- acquired acute bacterial prostatitis (CA-ABP) and ABP following transrectal ultrasound-guided prostate biopsy (Bx-ABP). METHODS: A total of 4,383 patients underwent prostate biopsy from January 2005 to June 2014. Among these patients, 34 had Bx-ABP; of which 22 patients had E. coli identified in their urine or blood culture. E. coli was also identified in 91 out of 209 patients with CA-ABP in urine or blood culture. We investigated patient and microbiological ch...
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research
CONCLUSION: Remote ischemic preconditioning did not modify irisin or troponin I expression, independent of the time of collection. PMID: 31799981 [PubMed - as supplied by publisher]
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
CONCLUSIONS: In this group of peritoneal dialysis patients, cystatin C did not correlate with the metabolic or inflammatory status, nor cardiovascular disease, after adjustment for residual renal function. PMID: 31799980 [PubMed - as supplied by publisher]
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
In this study, 48 PCV2 strains were isolated in China between 2016 and 2018 and the genetic diversity of these PCV2 isolates was determined. Results showed that these PCV2 isolates were classified into genotypes PCV2a (4 of 48), PCV2b (13 of 48) and PCV2d (31 of 48). Among them, 54.5% isolated in 2016, 65.2% isolated in 2017 and 71.4% isolated in 2018 belonged to PCV2d. It indicated that the prevalence of PCV2d genotype increased. All strains shared 93.4%-100% nucleotide sequence identity for the whole genome. Results of the analysis using RDP 4.0 molecular recombination software showed there were no recombinant events amo...
Source: Acta Virologica - Category: Infectious Diseases Authors: Tags: Acta Virol Source Type: research
Abstract For successful infection, viruses must recognize their respective host cells. A common mechanism of host recognition by viruses is to utilize a portion of the host cell as a receptor. Bacteriophage Sf6, which infects Shigella flexneri, uses lipopolysaccharide as a primary receptor and then requires interaction with a secondary receptor, a role that can be fulfilled by either outer membrane proteins (Omp) A or C. Our previous work showed that specific residues in the loops of OmpA mediate Sf6 infection. To better understand Sf6 interactions with OmpA loop variants, we determined the kinetics of these inter...
Source: Acta Virologica - Category: Infectious Diseases Authors: Tags: Acta Virol Source Type: research
In this study, full-length genome sequences of EsBV were pursued using next generation sequencing; the genome of EsBV was found to be composed of 6.7 kb L, 3.3 kb M, and 0.8 kb S segments, respectively. PCR detection based genomic sequences showed that the positive rate of EsBV reached 40% in crabs from farming ponds. EsBV had the highest similarity with the Wenling crustacean virus 9, an unassigned, negative sense ssRNA virus. EsBV clustered with the Wenling crustacean virus 9 firstly, and then the branch clustered with Peribunyaviridae clade in every phylogenetic tree - based on L, M and S encoded sequence...
Source: Acta Virologica - Category: Infectious Diseases Authors: Tags: Acta Virol Source Type: research
Abstract Betaflexiviridae is a family of plant-infecting RNA viruses with 11 recognized genera, of which genomes have diverse organization with three to six open reading frames (ORFs). A genome sequence of a novel Betaflexiviridae species, named Salvia divinorum RNA virus 1 (SdRV1), was identified in Salvia divinorum, herbal mint plant with hallucinogenic properties. The SdRV1 genome was predicted to have four ORFs encoding a replicase polyprotein (REP), a movement protein (MP), a coat protein (CP), and a putative nucleic acid-binding protein (NBP). Phylogenetic analyses based on the REP, MP, and CP sequences indi...
Source: Acta Virologica - Category: Infectious Diseases Authors: Tags: Acta Virol Source Type: research
This report describes how DINEPA and the US Centers for Disease Control and Prevention (CDC) collaborated to design and implement a training program for 264 potable water and sanitation technicians for rural areas. The paper also describes the initial field activities of the newly trained technicians and the immediate impact of their work in the rural water, sanitation and hygiene sector. PMID: 31798827 [PubMed]
Source: Journal of Water Sanitation and Hygiene for Development - Category: International Medicine & Public Health Tags: J Water Sanit Hyg Dev Source Type: research
Authors: Parra-Payano VD, Rondón-Paz CR, García C Abstract The study's objective was to determine the epidemiological, clinical, and laboratory characteristics of cases of invasive salmonellosis and the antibiotic susceptibility profile of salmonella isolates (2013-2017), in a series of cases of patients with Salmonella spp. isolated from secretions and/or body fluids with or without positive stool culture (n=70). For the evaluation of antibiotic susceptibility, the first isolate was considered in all cases of salmonellosis (n=168). The highest frequency of cases occurred between 0 to 4 years (14.3%) ...
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
This study supports previous findings of multidrug resistance in commensal strains in rural communities and highlights the increased rates of resistance over time. We recommend studies in larger populations with a longer follow-up. PMID: 31800939 [PubMed - in process]
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
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