Mechanisms Through Which Some Mitochondria-Generated Metabolites Act as Second Messengers That Are Essential Contributors to the Aging Process in Eukaryotes Across Phyla

Conclusions In this review, we analyzed mechanisms through which mitobolites, a distinct set of mitochondria-generated metabolites, can be released from mitochondria and then act as second messengers that contribute to cellular and organismal aging by regulating longevity-defining processes outside of mitochondria. Our analysis indicates that in eukaryotes across phyla, these second messengers of cellular aging exhibit the following common features: (1) they are produced in mitochondria in response to certain changes in the nutrient, stress, proliferation or age status of the cell; it remains unknown, however, what kind of protein sensors can respond to such changes by transmitting the signal to mitochondria so that mitochondria can increase the rates of catabolic and anabolic reactions producing these mitobolites; (2) their release from mitochondria and delivery to different non-mitochondrial locations within the cell also depend on these changes in the nutrient, stress, proliferation or age status of the cell; and (3) in cellular locations outside of mitochondria, they activate or inhibit a distinct set of protein sensors that in response set up a pro- or anti-aging cellular pattern by changing the efficiencies of certain pro- or anti-aging cellular processes; for some mitobolites, the identities of such protein sensors and/or mechanisms of their action are presently unknown. One important challenge is to define molecular mechanisms underlying the protein-mediated signalin...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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CONCLUSION: Patients with thyroid disease were found to have a higher risk for uveitis. For certain age groups or patients without diabetes or hypertension, the role of thyroid disease might be more crucial for uveitis development. PMID: 32643974 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ00581A, PaperRijith S, Sarika Sasidharan A novel electrocatalyst containing different percentage of Iron-Titanium mixed oxide onto graphene oxide (GO) support was prepared by embedding via thermal decomposition method (TD) and coated it on Cu substrate... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ02342F, PaperLi Gao, Zebin Deng, Yuanwei Lin, Husseini Sulemana, Haixia Shi, Chaosheng Yu, Shuaijun Chen The detection of cocaine based on aptamer modified molybdenum disulfide@gold nanoparticles (MoS2@AuNPs) nanosheet array immobilized on aminated slides was developed. Cocaine was detected using fluorescence energy resonance transfer between MoS2@AuNPs... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Authors: Müller T Abstract INTRODUCTION: Heterogeneity of symptoms and individual variability of progression characterizes Parkinson's disease. Unmet therapeutic needs include a cure, disease modification, and improvement of available marketed dopamine-substituting compounds. Personalized treatment, tailored to the patients' needs and symptoms, aims to ameliorate impaired motor behavior and non-motor features. Injection or infusion of apomorphine is a therapeutic option for more advanced patients with severe levodopa associated motor complications. AREAS COVERED: This narrative review summarizes the subcut...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Authors: Rocco D, Gregorc V, Della Gravara L, Lazzari C, Palazzolo G, Gridelli C Abstract INTRODUCTION: The development of immune checkpoint inhibitors (ICI) has represented a revolution in the treatment of non-small cell lung cancer (NSCLC) and has established a new standard of care for different settings. However, through adaptive changes, cancer cells can develop resistance mechanisms to these drugs, hence the necessity for novel immunotherapeutic agents. AREAS COVERED: This paper explores the immunotherapeutics currently under investigation in phase I clinical trials for the treatment of NSCLC as monotherap...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
In this report, a total of 860 publications related to TRPM7 were analyzed. Biophysical Journal ranked top for publishing 31 papers. The United States of America had the largest number of publications (320) with a high citation frequency (11,298) and H-index (58). Chubanov V (38 publications) and Gudermann T (38 citations), who from Ludwig Maximilian University of Munich, were the most productive authors and had the greatest co-citation counts. Our study also combined the bibliometric study with a systematic review on TRPM7, highlighting the four research frontiers of TRPM7. This is the first study that demonstrated the tr...
Source: Channels - Category: Molecular Biology Tags: Channels (Austin) Source Type: research
Publication date: Available online 9 July 2020Source: Preventive MedicineAuthor(s): Elizabeth M. Saewyc, Gu Li, Amy L. Gower, Ryan J. Watson, Darin Erickson, Heather L. Corliss, Marla E. Eisenberg
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Falls are a serious health problem in older adults. A limited number of studies assessed their multifactorial nature in geriatric ward patients. The aim of this study is to explore health, functional and nutritional correlates of experiencing fall(s) in th...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
BACKGROUND: Drug driving is an emerging global road safety problem. As the prevalence of alcohol-impaired driving decreases, and as more jurisdictions decriminalize or legalize cannabis, it is increasingly important for policy makers to have accurate infor...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
The classes below are what I am planning to take this fall. My cGPA is 3.62 and my sGPA is 3.4. Organic chemistry 1- 3 Biology of cancer- 2 Environmental physiology- 3 Principles of exercise training- 3 I am thinking of taking a biology course rather than the exercise training class. Should I be focused on taking science courses?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pre-Medical - MD Source Type: forums
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