Role of miRNA in the Transmission of Metabolic Diseases Associated With Paternal Diet-Induced Obesity

Conclusion The periconceptional environment and lifestyle factors modify sperm epigenome. This alteration might be maintained in the zygote and throughout development, thereby leading to the inheritance of newly acquired pathologies. The role of sperm miRNA, not only as innovative markers of fertility issues but also as vectors involved in the inheritance of paternal diseases, appears to be crucial. Overweight and obesity seem to alter sperm miRNA profile, thereby leading to transmission of different miRNA profiles in zygote, with consequences on embryo development. In long term, metabolic disorders have been described in offspring F1 and F2, and other pathologies may originate from paternal environment. In practice, this concept is important to know because it can help to predict and improve the periconceptional period, with a personalized management, and could be a powerful tool for infertility care. Indeed, paternal environment is too often neglected compared to the maternal environment. Identifying sperm miRNA profiles to predict risk of fertility alteration or noncommunicable disease inheritance is now required and needs further investigation, especially in randomized control trials in human. The impact of selected miRNA on IVF outcome, and the possibility to reverse or modify these miRNA profiles, requires our interest. Health professionals should pay more attention to the health of men of childbearing age. Author Contributions CD, LK, SS, VG, and RL participated...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research

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Conclusion: Our work represents the initial experience in the liver transplantation technique for thrombectomy in distinct and well-selected patients with atrial tumor thrombi. The effectiveness of this approach needs further study. The video presentation of our research took place in March 2019 at the 34th Annual EAU Congress in Barcelona. PMID: 32612649 [PubMed]
Source: Advances in Urology - Category: Urology & Nephrology Tags: Adv Urol Source Type: research
Publication date: Available online 2 July 2020Source: Ticks and Tick-borne DiseasesAuthor(s): Yang-yang Zhang, Dong-xiao Liu, Wen-bo Fan, Jin-hong Yu, Li Liu, Wen-jun Du, Qiang Li
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Publication date: Available online 2 July 2020Source: Artificial Intelligence in MedicineAuthor(s): Jacques Bouaud, Sylvia Pelayo, Jean-Baptiste Lamy, Coralie Prebet, Charlotte Ngo, Luis Teixeira, Gilles Guézennec, Brigitte Seroussi
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
Publication date: 15 November 2020Source: Journal of Molecular Structure, Volume 1220Author(s): Sithi Mgidlana, Pinar Şen, Tebello Nyokong
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
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Conclusions: Operative laparoscopy under conscious sedation and local anesthesia appears to be a feasible technique in gynecologic surgery with no adverse patient outcomes. PMID: 32612345 [PubMed - in process]
Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons - Category: Surgery Tags: JSLS Source Type: research
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Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons - Category: Surgery Tags: JSLS Source Type: research
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Source: Revista Latino-Americana de Enfermagem - Category: Nursing Authors: Tags: Rev Lat Am Enfermagem Source Type: research
CONCLUSION: it became evident that palliative care in primary health care has been gradually developed, but it is necessary to consider the organization of primary health care and the social policies that support or weaken it, being considered a complex challenge. PMID: 32609270 [PubMed - in process]
Source: Revista Latino-Americana de Enfermagem - Category: Nursing Authors: Tags: Rev Lat Am Enfermagem Source Type: research
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Source: Revista Latino-Americana de Enfermagem - Category: Nursing Authors: Tags: Rev Lat Am Enfermagem Source Type: research
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