Genetic Variants Associated with Cancer Therapy-Induced Cardiomyopathy.

CONCLUSIONS: Unrecognized rare variants in cardiomyopathy-associated genes, particularly TTNtv, increased the risk for CCM in children and adults, and adverse cardiac events in adults. Genotype, along with cumulative chemotherapy dosage and traditional cardiovascular risk factors improves identification of cancer patients at highest risk for CCM. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifiers: NCT01173341; AAML1031; NCT01371981. PMID: 30987448 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30987448?dopt=Abstract

Source: Circulation - April 15, 2019 Category: Cardiology Authors: Garcia-Pavia P, Kim Y, Alejandra Restrepo-Cordoba M, Lunde IG, Wakimoto H, Smith AM, Toepfer CN, Getz K, Gorham J, Patel P, Ito K, Willcox JA, Arany Z, Li J, Owens AT, Govind R, Nuñez B, Mazaika E, Bayes-Genis A, Walsh R, Finkelman B, Lupon J, Whiffin N, Tags: Circulation Source Type: research