Effect of setup and inter-fraction anatomical changes on the accumulated dose in CT-guided breath-hold intensity modulated proton therapy of liver malignancies

Liver cancer is one of the most common causes of cancer-related deaths [1,2]. Radiotherapy for liver cancer is difficult because of the low tolerance of the liver to radiation, sparing of adjacent normal structures, respiratory motion, and challenges in localizing the intrahepatic target during radiotherapy [3 –6]. Compared with radiotherapy with photons, e.g., intensity-modulated photon therapy (IMRT), proton therapy is characterized by a sharp dose fall-off around the target volume. Therefore, proton therapy can deliver a higher dose to liver tumor while preserving much more normal liver tissue than I MRT [1].

Source: Radiotherapy and Oncology - February 5, 2019 Category: Radiology Authors: Zhiyong Yang, Yu Chang, Kristy K. Brock, Guillaume Cazoulat, Eugene J. Koay, Albert C. Koong, Joseph M. Herman, Peter C. Park, Falk Poenisch, Qin Li, Kunyu Yang, Gang Wu, Brian Anderson, Andrea N. Ohrt, Yupeng Li, X. Ronald Zhu, Xiaodong Zhang, Heng Li Tags: Original Article Source Type: research