Gene therapy cures infants with ‘bubble boy’ immune disease

After years of heartbreaking setbacks, researchers say they can restore immune systems in SCID babies.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news

Related Links:

Publication date: Available online 21 February 2020Source: Progress in Natural Science: Materials InternationalAuthor(s): Chunyan Zhu, Zhao Chen, Shuai Gao, Ban Leng Goh, Ismail Bin Samsudin, Kai Wen Lwe, Yunlong Wu, Caisheng Wu, Xiaodi SuAbstractQuantum dots (QDs) with unique quantum confinement effect and electro-optical properties are attractive for biomedical applications. Toxic effects of traditional semiconductor QDs made of heavy metal ions have serious safety concerns for their undesired environmental or healthy impact. Recent reports on core-shell structure modification of QDs by using biocompatible ligands or pol...
Source: Progress in Natural Science: Materials International - Category: Materials Science Source Type: research
CONCLUSIONS: Severe SE, not outcomes, was the most decisive attribute determining future HCRCT participation. Particular attention should be paid to providing clear information, in particular on severe SE, to potential participants. Immunotherapy would appear to be the best HCRCT candidate for both PLWH and physicians. However, if the risk of cancer could be avoided, gene therapy would become the preferred strategy for the latter and the second choice for the former. PMID: 32077248 [PubMed - in process]
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
p19Arf sensitizes B16 melanoma cells to interferon-β delivered via mesenchymal stem cells in vitro. Braz J Med Biol Res. 2020;53(3):e8876 Authors: Da-Costa RC, Vieira IL, Hunger A, Tamura RE, Strauss BE Abstract The immune stimulatory and anti-neoplastic functions of type I interferon have long been applied for the treatment of melanoma. However, the systemic application of high levels of this recombinant protein is often met with toxicity. An approach that provides localized, yet transient, production of type I interferon may overcome this limitation. We propose that the use of mesenchymal stem ...
Source: Braz J Med Biol Res - Category: Research Authors: Tags: Braz J Med Biol Res Source Type: research
Publication date: Available online 21 February 2020Source: Journal of Molecular LiquidsAuthor(s): Francisco J. Ostos, José A. Lebrón, Pilar López-Cornejo, Manuel López-López, Margarita García-Calderón, Clara B. García-Calderón, Ivan V. Rosado, Vitaly I. Kalchenko, Roman V. Rodik, María Luisa MoyáAbstractThe self-aggregation of four amphiphilic cationic calix[4]arenes, CALIX, in aqueous solutions was investigated in this work. The nature of the polar group present at the upper rim as well as the length of the hydrophobic tails attached to the lower...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
ConclusionIn conclusion, ALO –Adbic combination can produce synergistic anti-cancer effects at low doses, and may offer a more effective and less toxic new treatment strategy for NSCLC.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Publication date: March 2020Source: Journal of Vascular and Interventional Radiology, Volume 31, Issue 3, SupplementAuthor(s): F. Zhang, S. Gao, X. Yang
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
This webinar will focus on the common pitfalls encountered during the startup phase of cell and gene therapy facilities, with special emphasis on lessons learned in the CMO space.(PRWeb February 21, 2020)Read the full story at
Source: PRWeb: Medical Pharmaceuticals - Category: Pharmaceuticals Source Type: news
Publication date: Available online 20 February 2020Source: Materials Chemistry and PhysicsAuthor(s): Bashir Mosayyebi, Mahsa Imani, Leila Mohammadi, Abolfazl Akbarzadeh, Nosratollah Zarghami, Mahdi Edalati, Effat Alizadeh, Mohammad RahmatiAbstractCyanogenic glycosides are defined as natural herbal toxins which are found in more than 2000 plant species and most of them consumed by humans. These nitrile-containing compounds do not present toxic effects in intact form while they produce toxic cyanide following enzymatic digestion. Therefore, over-consuming of these compounds can lead to cyanide poisoning. On the other hand, s...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
Human Gene Therapy, Ahead of Print.
Source: Human Gene Therapy - Category: Genetics & Stem Cells Authors: Source Type: research
More News: Babies | Gene Therapy | Genetics | Health