Yale study revives cellular activity in pig brains hours after death

Yale University scientists have succeeded in restoring basic cellular activity in pigs' brains hours after their deaths in a finding that may one day lead to advances in treating human stroke and brain injuries, researchers reported on Wednesday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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CONCLUSIONS: In 55,3% of patients, the 061 response time was greater than 60 minutes, but this time were not conditioned by the activation time. However, there were differences in the percentage of cases fibrinolysed in the different time intervals, suggesting that factors other than the response time of 061 influence the indication of fibrinolytic treatment. PMID: 31713227 [PubMed - in process]
Source: Revista de Neurologia - Category: Neurology Authors: Tags: Rev Neurol Source Type: research
Publication date: Available online 12 November 2019Source: Canadian Journal of CardiologyAuthor(s): Mohammed Shurrab, Asaf Danon, Sami Alnasser, Benedict Glover, Anna Kaoutskaia, Mark Henderson, David Newman, Eugene Crystal, Dennis KoAbstractBackgroundThe choice of antithrombotic therapy for atrial fibrillation (AF) patients who have an acute coronary syndrome (ACS) or have undergone percutaneous coronary intervention (PCI) is challenging. We aimed to assess outcomes between dual antithrombotic therapy with DOACs plus an antiplatelet agent (Dual therapy) in comparison to warfarin plus two antiplatelet agents (Triple therap...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
ConclusionsAlthough most high-risk patients with T2D and CV disease were on lipid-lowering therapy, only 1:3 had LDL-C 
Source: American Heart Journal - Category: Cardiology Source Type: research
Publication date: Available online 12 November 2019Source: Progress in NeurobiologyAuthor(s): Joseph H. Neale, Tatsuo YamamotoAbstractN-Acetylaspartylglutamate (NAAG) is the third most prevalent neurotransmitter in the mammalian nervous system, yet its therapeutic potential is only now being fully recognized. Drugs that inhibit the inactivation of NAAG by glutamate carboxypeptidase II (GCPII) increase its extracellular concentration and its activation of its receptor, mGluR3. These drugs warrant attention, as they are effective in animal models of several clinical disorders including stroke, traumatic brain injury and schi...
Source: Progress in Neurobiology - Category: Neuroscience Source Type: research
Publication date: Available online 13 November 2019Source: Clinica Chimica ActaAuthor(s): Julia Oto, Álvaro Fernández-Pardo, Manuel Miralles, Emma Plana, Francisco España, Silvia Navarro, Pilar MedinaAbstractActivated protein C (APC) acts as an “on demand” anticoagulant, reducing thrombin formation. Reduced plasma levels of APC or protein C (PC) are associated with an increased risk of venous thromboembolism. APC also displays cytoprotective functions and its therapeutic use has been evaluated in severe sepsis and is under evaluation in several diseases with an important inflammatory compon...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Temporary middle cerebral artery occlusion (MCAO) in sheep allows modeling of acute large vessel occlusion stroke and subsequent vessel recanalization. However, rapid and precise imaging-based assessment of vessel occlusion and the resulting perfusion deficit during MCAO still represents an experimental challenge. Here, we tested feasibility and suitability of a strategy for MCAO verification and perfusion deficit assessment. We also compared the extent of the initial perfusion deficit and subsequent lesion size for different MCAO durations. The rete mirabile prevents reliable vascular imaging investigation of middle cereb...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Authors: Yoshida K, Miyamoto S, SMART-K Study Group Abstract With recent advances in medical treatments for carotid artery stenosis (CS), indications for carotid surgery should be more carefully considered for asymptomatic CS (ACS). Accurate stratification of ACS should be based on the risk of cerebral infarction, and subgroups of patients more likely to benefit from surgical treatment should be differentiated. Magnetic resonance imaging (MRI) offers a non-invasive, accurate modality for characterizing carotid plaque. Intraplaque hemorrhage (IPH) seems the most promising feature of vulnerable plaque detectable by M...
Source: Neurologia Medico-Chirurgica - Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research
Conditions:   Stroke, Ischemic;   Self Efficacy Intervention:   Behavioral: The effect of education and telephone follow ups based on the Chronic Care Model on self-management, quality of life and patient satisfaction in patients with ischemic stroke Sponsor:   Akdeniz University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
WEDNESDAY, Nov. 13, 2019 -- Regular exercise lowers older adults'risk of heart disease and stroke, even if they have health problems such as high blood pressure or diabetes, researchers say. For the new study, researchers analyzed data from more...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Conditions:   Stroke, Ischemic;   Self Efficacy Intervention:   Behavioral: The effect of education and telephone follow ups based on the Chronic Care Model on self-management, quality of life and patient satisfaction in patients with ischemic stroke Sponsor:   Akdeniz University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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