Combined Adjuvant of Poly I:C Improves Antitumor Effects of CAR-T Cells

In conclusion, CAR-T treatment combined with intratumoral delivery of poly I:C resulted in synergistic antitumor activity. We thus provide a rationale to translate this immunotherapeutic strategy to solid tumors. Introduction Adoptive T cell immunotherapy has been demonstrated to be a new way to fight malignancies. In particular, T lymphocytes engineered to express chimeric antigen receptor (CAR) have shown great promise in treating hematological malignancies (1). CD19-targeted CAR-T cells have been approved by FDA to treat relapsed B cell acute lymphoblastic leukemia (B-ALL) and Diffuse Large B-cell lymphoma (DLBCL) (2, 3). CAR-T therapy is also a novel approach to treat other malignant tumors. Currently, Glypian-3 (GPC3), epidermal growth factor receptor (EGFR), human epidermal growth factor receptor2 (HER2), carcinoembryonic antigen (CEA), disialoganglioside 2 (GD2), mesothelin, prostate-specific membrane antigen (PSMA), and interleukin-13Ra2 (IL13Ra2) have been tested as targets of CAR-T cells in solid tumor. However, CAR-T therapy for solid tumors has not been as efficient as those targeting hematologic malignancies (4–7). The reasons for the limited success of CAR T cells in solid tumor are being actively investigated, and are likely multifactorial. One major reason is the immunosuppressive microenvironment that may impede the function and persistence of CAR T cells. This includes the presence of regulatory T cells, tumor-associated macrophages, myeloid-...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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Authors: Turan AS, Ultee G, Van Geenen EJM, Siersema PD Abstract INTRODUCTION: The most commonly used treatment for advanced colorectal adenomas is endoscopic mucosal resection (EMR). The increased number of EMRs since the introduction of the screening program for colorectal cancer has resulted in an increase in EMR-related complications. This review summarizes the current knowledge for the use of clips for the treatment and prevention of complications after EMR. Areas covered: The historical development of clips is summarized and their properties are evaluated. An overview is presented of the evidence for therapeu...
Source: Expert Review of Medical Devices - Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research
Chem. Commun., 2019, Advance Article DOI: 10.1039/C9CC01506J, CommunicationYuan Ma, Quanbing Mou, Lijuan Zhu, Yue Su, Xin Jin, Jing Feng, Deyue Yan, Xinyuan Zhu, Chuan Zhang Polygemcitabine nanogels assembled from DNA-like polygemcitabine undergo rapid intracellular degradation to generate active gemcitabine derivatives for enhanced cancer therapy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
AbstractObjectiveTo evaluate factors associated with use of patient navigation in a prostate cancer population and identify whether navigation is associated with prolonged  time to care. Cancer patient navigation has been shown to improve access to cancer screening, diagnosis, and treatment, but little is known about patient navigation in prostate cancer care.MethodsAll men diagnosed with localized prostate cancer between 2009 and 2015 were abstracted from the MaineHealth  multi-specialty tumor registry. Regression analyses controlling for patient-, disease-, and system-level factors evaluated characteristics ass...
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionIn conclusion, this study illustrates that the application and benefits of HS on reducing GI rectal dose endpoints and toxicities during prostate cancer RT can be reliably replicated in a community setting similar to centres participating in the randomised trial under high quality assurance trial monitoring.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionThere is a need to enhance a constant patient –HCP dialogue, and both groups need to make a conscious effort in that direction. This would help in increasing patients’ awareness of risks, having better treatment choice and acceptance, and reducing side-effects.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
(copied from reddit) Hey guys, So I wanted to follow up on a previous thread I started, which discussed some obstacles and hardships I faced as an undergrad, which included losing my mom to cancer over the course of 2 years. In short, this left me broken mentally, physically, and a scar on my academic career. My GPA was significantly impacted and it decreased incredibly through those years, however, the past 3... What to do next? Graduate and kind of lost right now
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Nontraditional Students Source Type: forums
Publication date: Available online 21 May 2019Source: Journal of Environmental PsychologyAuthor(s): Emmy van Esch, Robert Minjock, Stephen M. Colarelli, Steven HirschAbstractA growing number of organizations are re-designing workplaces to give employees greater exposure to natural views, which frequently improve well-being. But what is it about views of nature that produce these benefits? Is it the overall view or the particular features within a view? If it is features, what features have the greatest effects on well-being, and are these features particular to natural settings or might they generalize to built settings? W...
Source: Journal of Environmental Psychology - Category: Psychiatry & Psychology Source Type: research
Publication date: August 2019Source: Journal of Functional Foods, Volume 59Author(s): Bernadetta Lis, Beata OlasAbstractSince ancient times, dandelion (Taraxacum officinale L.) has been consumed in various forms as a valuable source of nutrients, minerals and vitamins which can also have beneficial effects on various complex diseases. It is described as a nontoxic herb with exceptional biological activity. The aim of this review is to present the multidirectional activity of various dandelion products whose dietary intake may help to prevent, or reduce the risk of, the development of a range of diseases, including cancer, ...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Hello. It's been three years since I graduated from my undergrad university. I graduated with a 2.94 overall gpa and 2.0 science gpa. During college my mother was diagnosed with cancer and my father simultaneously lost his job. Along with these stressors and immature study habits, I just didn't place importance on school work. Since graduating, I have taken some post-bacc classes informally at a cc near my house. Made all A's in them. Then, I joined a one year masters program to gain a... Nontrad applicant chance me
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: What Are My Chances? WAMC Dental Source Type: forums
Reported cases of mumps and pertussis have risen in the US in recent years even though many people are vaccinated. As part of the FDA commitment to protect the public health, FDA scientists are working to learn why more cases are occurring.
Source: FDA Consumer Health Information Updates - Category: Consumer Health News Authors: Source Type: news
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