Multigene Mutation Profiling and Clinical Characteristics of Small-Cell Lung Cancer in Never-Smokers vs. Heavy Smokers (Geno1.3-CLICaP)

Conclusion: Our data supports that never/ever smoker patients with small-cell lung cancer have better prognosis compared to their smoker counterparts. Further, patients with never/ever smoking history who present with small-cell lung cancer have a different mutation profile compared with smokers, including a high frequency of EGFR, MET, and SMAD4 mutations. Further studies are required to assess whether the differential mutation profile is a consequence of a diverse pathological mechanism for disease onset. Introduction Lung cancer is the most common neoplasia worldwide. Aside from the high incidence, lung cancer also leads the list in terms of mortality, with the highest number of cancer-related deaths attributed to this tumor type. In this sense, lung cancer accounts for the lowest 5-year survival rate among other prevalent neoplasms, and therefore represents a significant healthcare burden worldwide (1, 2). Nonetheless, lung cancer is a heterogeneous disease, and it can be categorized in terms of the major histological subtypes, which include adenocarcinoma, squamous cell, small cell and large cell carcinoma. Cigarette smoking is the best characterized lung cancer risk factor, and it is associated with a 19-fold increase in the risk of developing the disease, especially in women (3). Furthermore, it is responsible for 80–90% of lung cancer cases. Small cell lung carcinoma (SCLC) appears to have the strongest correlation with smoking status compared with othe...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

Related Links:

Authors: Pennisi PA, Fernández MC, Martin A Abstract Pheochromocytomas/paragangliomas (PCCs/PGLs) are rare neuroendocrine tumors, developed from chromaffin cells derived from the neural crest. From a genetic point of view PCCs/PGLs are divided as sporadic cases, and inherited cases as part of hereditary (familial) syndromes. While the majority is benign, up to 26% of PCCs/PGLs will undergo malignant transformation. Validated prognostic pathological parameters for malignant PCCs/PGLs are still lacking. Signaling that follows the interactions between IGFs and their receptor/s in tumor cells received extensive ...
Source: Pediatric Endocrinology Reviews - Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
The turmoil and devastating destruction of World War II had also ruined dermatology across Europe. In contrast, the Society of Investigative Dermatology (SID; founded in 1937) in the United States functioned successfully and soon became a role model for the leaders of dermatology departments in  various European countries. Our former teachers in dermatology succeeded in overcoming the prejudice and animosity in the western world. This outcome was the conception of the founding fathers (there was no founding lady in the initial group) of the European Society for Dermatological Research (ES DR).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Personal Views & Reflections Source Type: research
On behalf of all the Japanese Society for Investigative Dermatology (JSID) members, we would like to congratulate the European Society for Dermatological Research (ESDR) on its 50th anniversary! It must have been a long and winding road to achieve the current big success of ESDR, which always provides a harmonious and welcoming atmosphere to people attending its meetings from around the world. Although each country in European communities has a different background, ESDR unites people with the same aim to advance investigative dermatology and cutaneous biology.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: ESDR – A Gateway for Global Interactions Source Type: research
When I started my clinical training in dermatology in 1981 and got involved in basic research in 1984, in those days for young German-speaking dermatology researchers, there was one important scientific meeting, the meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF, Association of Dermatological Research). Presenting an abstract at this meeting was a must, and having been selected for oral presentation was an extraordinary achievement. There was another extremely important forum, the meeting of the Society of Investigative Dermatology (SID).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Personal Views & Reflections Source Type: research
Source: Journal of Dentistry for Children - Category: Dentistry Authors: Tags: Scientific Articles Source Type: research
Source: Journal of Dentistry for Children - Category: Dentistry Authors: Tags: Clinical Article Source Type: research
Authors: Guo FF, Jiang MM, Hong LL, Qiao B, Lin XM, Xu WY, Fu XQ Abstract Since this article has been suspected of research misconduct and the corresponding authors did not respond to our request to prove originality of data and figures, "Long non-coding RNA OR3A4 promotes metastasis of ovarian cancer via inhibiting KLF6, by F.-F. Guo, M.-M. Jiang, L.-L. Hong, B. Qiao, X.-M. Lin, W.-Y. Xu, X.-Q. Fu, published in Eur Rev Med Pharmacol Sci 2019; 23 (6): 2360-2365-DOI: 10.26355/eurrev_201903_17380-PMID: 30964160" has been withdrawn. The Publisher apologizes for any inconvenience this may cause. https://www.e...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: Prescribing pattern analysis showed the highest responses and remission rates with tocilizumab and TNF-α inhibitors. The main reasons for withdrawal were lack of response and adverse effects. Further research is needed to improve pharmacological RA management in real-life settings. PMID: 32767346 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Zhao YL, Yuan BQ, Shen GS Abstract OBJECTIVE: To explore the mechanism of RET gene mediated EGFR signaling pathway on the epithelial-mesenchymal transition (EMT), proliferation and apoptosis of papillary thyroid carcinoma (PTC) cells. PATIENTS AND METHODS: PTC TPC-1 cells and human normal thyroid follicular epithelial cells Nthy-ori 3-1 were collected to identify the expression of RET in PTC. Seven groups were divided according to different transfection protocols, including blank group, negative control group, si-RET group, oe-RET group, AG-490 group, NSC 228155 group, and si-RET + NSC 228155 group. Af...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: de Sire A, Losco L, Cisari C, Gennari A, Boldorini R, Fusco N, Cigna E, Invernizzi M Abstract OBJECTIVE: Axillary web syndrome (AWS) is a complication of surgical procedures in breast cancer (BC) patients. This condition with poorly understood incidence and etiology is characterized by the locoregional development of scar tissue, leading to subcutaneous cording, motion impairment and pain. The early identification of patients at risk for AWS would improve their clinical management. Here, we sought to characterize the prevalence of and the risk factors associated with AWS in BC women after surgery. PATI...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
More News: Academia | Adenocarcinoma | Argentina Health | Biology | Brain | Brain Cancers | Brazil Health | Cancer | Cancer & Oncology | Cancer Therapy | Carcinoid Tumor | Carcinoma | Chemotherapy | Colombia Health | Conferences | Costa Rica Health | Databases & Libraries | Environmental Health | Epidemiology | Eye Cancers | Genetics | Germany Health | Hematology | Immunotherapy | Japan Health | Lung Cancer | Medical Ethics | Mexico Health | Molecular Biology | Neurology | Non-Small Cell Lung Cancer | Oral Cancer | Pathology | Reproduction Medicine | Retinoblastoma | Small Cell Lung Cancer | Smokers | Spain Health | Squamous Cell Carcinoma | Statistics | Students | Study | Sweden Health | Tarceva | Texas University | Universities & Medical Training | USA Health | Women | Yervoy