GSE85197 RNA-seq of N2a cells treated with 100 nM Dexamethasone for 4 hours +/- siARGLU1

Contributors : Lilia Magomedova ; Serge Gueroussov ; Manuel Irimia ; Benjamin J Blencowe ; Carolyn L CumminsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusARGLU1 was identified in a screen for new modulators of glucocorticoid signaling in the CNS. RNA-seq of neuronal cells ±siARGLU1 revealed significant changes in the expression and alternative splicing of distinct genes involved in neurogenesis. Treatment with dexamethasone, a GR activator, also induced changes in the pattern of alternatively spliced genes, highlighting an underappreciated global mechanism of glucoc orticoid action in neuronal cells. Thus, in addition to its basal role, ARGLU1 links glucocorticoid-mediated transcription and alternative splicing in neural cells, providing new avenues from which to investigate the molecular underpinnings of cognitive stress disorders.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research