1,2,4-oxadiazole-5-ones as analogues of tamoxifen: synthesis and biological evaluation

Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00651F, PaperAgata Campisi, Maria Assunta Chiacchio, Laura Legnani, Paola Bottino, Giuseppe Lanza, Daniela Iannazzo, Lucia Veltri, Salvatore V. Giofr è, Roberto ROMEO A series of 2,3,4-triaryl-substituted 1,2,4-oxadiazole-5-ones have been prepared as fixed-ring analogues of tamoxifen (TAM), a drug inhibitor of Estradiol Receptor (ER) used in breast cancer therapy, by an efficient synthetic... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research