Molecules, Vol. 24, Pages 1516: Advances in the Understanding of Skin Cancer: Ultraviolet Radiation, Mutations, and Antisense Oligonucleotides as Anticancer Drugs
Molecules, Vol. 24, Pages 1516: Advances in the Understanding of Skin Cancer: Ultraviolet Radiation, Mutations, and Antisense Oligonucleotides as Anticancer Drugs
Molecules doi: 10.3390/molecules24081516
Authors:
Laikova
Oberemok
Krasnodubets
Gal’chinsky
Useinov
Novikov
Temirova
Gorlov
Shved
Kumeiko
Makalish
Bessalova
Fomochkina
Esin
Volkov
Kubyshkin
Skin cancer has always been and remains the leader among all tumors in terms of occurrence. One of the main factors responsible for skin cancer, natural and artificial UV radiation, causes the mutations that transform healthy cells into cancer cells. These mutations inactivate apoptosis, an event required to avoid the malignant transformation of healthy cells. Among these deadliest of cancers, melanoma and its ‘younger sister’, Merkel cell carcinoma, are the most lethal. The heavy toll of skin cancers stems from their rapid progression and the fact that they metastasize easily. Added to this is the difficulty in determining reliable margins when excising tumors and the lack of effective chemotherapy. Possibly the biggest problem posed by skin cancer is reliably detecting the extent to which cancer cells have spread throughout the body. The initial tumor is visible and can be removed, whereas metastases are invisible to the naked eye and much harder to eliminate. In our opinion, antisense oligonucleotides, which can be used in the form of targeted ...
Source: Molecules - Category: Chemistry Authors: Laikova Oberemok Krasnodubets Gal ’chinsky Useinov Novikov Temirova Gorlov Shved Kumeiko Makalish Bessalova Fomochkina Esin Volkov Kubyshkin Tags: Review Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | Chemistry | Chemotherapy | Melanoma | Merkel Cell Carcinoma | Skin | Skin Cancer