Systematic Review and Meta-Analysis Confirms Significant Contribution of Surfactant Protein D in Chronic Obstructive Pulmonary Disease

Conclusion: Serum concentration and alleleic conformation of SFTPD has a significantly high predictive value for COPD and AECOPD. Thus, these can be tested further and could be applied as a predictive or prognostic marker. Introduction Chronic Obstructive Pulmonary Disease (COPD) affects lungs and exhibits irreversible airflow conditions that leads to improper respiratory function (Carolan et al., 2014). COPD is a global disease burden which accounts for ~3 million deaths annually (Zemans et al., 2017) and is responsible for the increase in worldwide mortality and morbidity (Dickens et al., 2011). Chronic Obstructive Pulmonary Disease is projected to be the third leading cause of death by 2020 (Dickens et al., 2011). Chronic Obstructive Pulmonary Disease has multiple sub-phenotypic conditions like emphysema, lean body mass, mucus hypersecretion, and acute exacerbation (Dickens et al., 2011; Shakoori et al., 2012; Carolan et al., 2014). Each sub-phenotype is considered to be the outcome of different immune related pathways which are involved in COPD pathogenesis (Ishii et al., 2012). Surfactant protein D (SF-D or SFTPD) is a highly lung specific glycoprotein secreted by type II alveolar cells and non-ciliated clara cells and functionally involved in maintaining the lung functions (Shakoori et al., 2012; Akiki et al., 2016). This multimeric glycoprotein belongs to lectin super family (Moreno et al., 2014) and takes part in immune regulation and maintenance of lung func...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research

Related Links:

Conclusion: Actual intake of sulphite for average consumers was well below the ADI but for high consumers was approaching the ADI. People with sulphite sensitivity need to be aware of hidden food sources of sulphites.
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
Conclusion: The study is the first report on microbial profiling of microflora of starters. A careful examination of individual components and method of preparation of the starters should be taken to avoid contamination by pathogens.
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
Conclusion: These findings suggest that a pro-inflammatory diet is a risk factor for prostate cancer and also can have the impact on body composition.
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
Conclusion: Taken together, AFPE that acts at a low micromolar range against breast cancer cells may be considered as a promising candidate for anticancer therapy.
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
Conclusion: For the first time, para-aminobenzoic acid was well determined by incorporating it as an organic solid compound, 4(4-Benzophenylazo)pyrogallol, through coupling pyrogallol with diazotized para-aminobenzoic acid in regulated pH medium, ranging between 5.0 to 6.0. The existence of common excipients in the dietary supplement did not produce any significant interference. F- and ttest data analysis were used for statistical comparison of the suggested techniques with that of reference method, demonstrating excellent agreement with no significant difference in the associated precision and accuracy.
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
Two midwives in New Mexico help empower Native American women who are navigating their maternal care options. Watch the full "Giving Birth in America: New Mexico" documentary produced by Every Mother Counts.
Source: - Health - Category: Consumer Health News Source Type: news
ConclusionFor the first time, we described the PKD phenotype in association with CTA/CTG expansion, suggesting that CTA/CTG expansion might play a role in the pathogenesis of paroxysmal dyskinesia symptoms.
Source: Journal of Neurology - Category: Neurology Source Type: research
Since Invitae’s inception a decade ago, the firm has been working for the proactive use of genetic information in mainstream medicine. The San Francisco, CA-based company has been using M&A activity to help bring companies under its tent to help make this goal a reality. On Monday, the genetic-testing specialist made more progress on this front by announcing it would put down $50 million to acquire Clear Genetics, a company that develops digital counseling software. San Francisco, CA-based Clear Genetics has developed Gia, a chatbot that equips patients with actionable information throughout the genetic t...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Software Source Type: news
John Davies' blood cells will be genetically modified in a US lab in the hope of curing him.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Abstract Sex hormones are best known for their influences on reproduction, but they also have profound influences on the immune response. Examples of sex-specific differences include: (i) the relatively poor control of influenza virus infections in males compared to females, (ii) allergic asthma, an IgE-associated hypersensitivity reaction that is exacerbated in adolescent females compared to males, and (iii) systemic lupus erythematosus, a life-threatening autoimmune disease with a 9:1 female:male bias. Here we consider how estrogen and estrogen receptor α (ERα) may influence the immune response by mo...
Source: Cellular Immunology - Category: Allergy & Immunology Authors: Tags: Cell Immunol Source Type: research
More News: Academia | Alpha-1 Antitrypsin Deficiency | Asthma | Calcium | Cancer | Cancer & Oncology | Carbohydrates | Children | China Health | Chronic Obstructive Pulmonary | CT Scan | Databases & Libraries | Emphysema | Environmental Health | Genetics | Germany Health | Grants | India Health | International Medicine & Public Health | Japan Health | Lebanon Health | Lung Cancer | Mexico Health | Pakistan Health | PET Scan | Pneumonia | Pulmonary Function Testing | Reproduction Medicine | Respiratory Medicine | Science | Smokers | Sports Medicine | Statistics | Study | University of Pennsylvania | USA Health