Systematic Review and Meta-Analysis Confirms Significant Contribution of Surfactant Protein D in Chronic Obstructive Pulmonary Disease

Conclusion: Serum concentration and alleleic conformation of SFTPD has a significantly high predictive value for COPD and AECOPD. Thus, these can be tested further and could be applied as a predictive or prognostic marker. Introduction Chronic Obstructive Pulmonary Disease (COPD) affects lungs and exhibits irreversible airflow conditions that leads to improper respiratory function (Carolan et al., 2014). COPD is a global disease burden which accounts for ~3 million deaths annually (Zemans et al., 2017) and is responsible for the increase in worldwide mortality and morbidity (Dickens et al., 2011). Chronic Obstructive Pulmonary Disease is projected to be the third leading cause of death by 2020 (Dickens et al., 2011). Chronic Obstructive Pulmonary Disease has multiple sub-phenotypic conditions like emphysema, lean body mass, mucus hypersecretion, and acute exacerbation (Dickens et al., 2011; Shakoori et al., 2012; Carolan et al., 2014). Each sub-phenotype is considered to be the outcome of different immune related pathways which are involved in COPD pathogenesis (Ishii et al., 2012). Surfactant protein D (SF-D or SFTPD) is a highly lung specific glycoprotein secreted by type II alveolar cells and non-ciliated clara cells and functionally involved in maintaining the lung functions (Shakoori et al., 2012; Akiki et al., 2016). This multimeric glycoprotein belongs to lectin super family (Moreno et al., 2014) and takes part in immune regulation and maintenance of lung func...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research

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