Assessing the relationship between statin use and oncologic outcomes among men electing active surveillance for localized prostate cancer

Assessing the relationship between statin use and oncologic outcomes among men electing active surveillance for localized prostate cancerAssessing the relationship between statin use and oncologic outcomes among men electing active surveillance for localized prostate cancer, Published online: 17 April 2019; doi:10.1038/s41391-019-0147-0Assessing the relationship between statin use and oncologic outcomes among men electing active surveillance for localized prostate cancer
Source: Prostate Cancer and Prostatic Diseases - Category: Urology & Nephrology Authors: Source Type: research

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Source: OnMedica Latest News - Category: UK Health Source Type: news
ConclusionMetformin and statins were not associated with BFFS or DFFS improvement in our analysis. However, the small number of patients treated with these drugs limits the reliability of the results and prospective studies are needed.
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
MONDAY, Dec. 2, 2019 -- Current statin use is inversely associated with the risk for lethal prostate cancer, according to a study published online Nov. 21 in Clinical Cancer Research. Emma H. Allott, Ph.D., from Queen's University Belfast in the...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Researchers at Queen's University in Belfast suggested the cholesterol-lowering drugs could reduce swelling the prostate and avoid deadly cancer, but overall rates of cancer were unchanged.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
CONCLUSIONS: Molecular tumor classification identified PTEN and inflammation/immune activation as potential mechanisms linking statins with lower lethal prostate cancer risk. These findings support a potential causal association and could inform selection of relevant biomarkers for statin clinical trials. PMID: 31754047 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
The association between statins therapy and prostate cancer is extensively studied [1,2]. Recently, one cohort study conducted by Van Rompay et  al. published in European Journal of Cancer demonstrated that statins use was associated with a lower mortality of prostate cancer than non-use (hazard ratio 0.73, 95% confidence interval 0.66–0.81) [3]. This result was compatible with another cohort study in Finland showing that statins use aft er prostate cancer diagnosis was associated with 20% reduced mortality of prostate cancer (hazard ratio 0.80, 95% confidence interval 0.65–0.98) [4].
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Letter to the Editor Source Type: research
We found that statin use might be associated with reduced risk of both low ‐ and high‐grade prostate cancer, but the reduced risk was observed only when statins had been used for a relatively longer duration or higher dose. Also, the statin‐related risk reduction was higher for prostate cancer of a higher Gleason score, and lipophilic statins might be more protective than hydrophilic statins against prostate cancer. AbstractBackgroundConflicting evidence suggests that statins act chemopreventively against prostate cancer (PCa). Whether the association of statin use with PCa risk is Gleason score ‐dependent, time‐...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
ConclusionsOur findings show that oncologists and physicians have a rational approach to deprescription in patients suffering from cancer with short-term (pancreatic and lung cancer) respectively long-term (breast and prostate cancer) survival rates. However, several patients were continuing potential inappropriate medications in the terminal stage of cancer.Legal entity responsible for the studyThe authors.FundingHas not received any funding.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsThese analyses suggest the pharmacokinetic profile of darolutamide is not affected by a number of commonly administered drugs in patients with nmCRPC. Although pharmacokinetic data have indicated that darolutamide has the potential to interact with rosuvastatin, used to assess DDI in these studies, this finding did not seem to translate into increased AEs due to statin use in the ARAMIS trial.Clinicaltrials.gov identifier: NCT02200614.
Source: Targeted Oncology - Category: Cancer & Oncology Source Type: research
onomura Prostate cancer is the most common type of cancer and the leading cause of cancer deaths among men in many countries. Preventing progression is a major concern for prostate cancer patients on active surveillance, patients with recurrence after radical therapies, and patients who acquired resistance to systemic therapies. Inflammation, which is induced by various factors such as infection, microbiome, obesity, and a high-fat diet, is the major etiology in the development of prostate cancer. Inflammatory cells play important roles in tumor progression. Various immune cells including tumor-associated neutrophils, ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
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