Synchronous Mixed Germ Cell Tumor of Testis and Renal Cell Carcinoma: A rare presentation
ConclusionTreatment strategies for both malignancies depend on accurate clinical staging and should be integrated to provide optimal results.
Authors: Chang C, Wu H, Lu Q Abstract Food allergy is a global health problem, particularly in developed countries. It is mainly mediated by Th2 cell and IgE produced by B cells. While the pathogenesis of IgE-mediated food allergy is quite straightforward, the factors that lead to the development of food allergies at any age in children and adults are unclear. Recent studies have revealed that genetics, epigenetics, and environmental exposures contribute to the development of atopy. In this chapter, we discuss the interplay between these three key elements, reveal how epigenetic modifications may mediate genetic su...
Authors: Ceribelli A, Selmi C Abstract Genomic predisposition fails to fully explain the onset of complex diseases, which is well illustrated by the largely incomplete concordance among monozygotic twins. Epigenetic mechanisms, including DNA methylation, chromatin remodeling, and non-coding RNA, are the link between environmental stimuli and disease onset on a permissive genetic background in autoimmune and chronic inflammatory diseases. Autoimmune diseases now include almost 100 conditions and are estimated to cumulatively affect up to 5% of the world population with a healthcare expenditure superior to cancer wor...
Authors: Zhang L, Lu Q, Chang C Abstract Epigenetic mechanisms, which include DNA methylation, histone modification, and microRNA (miRNA), can produce heritable phenotypic changes without a change in DNA sequence. Disruption of gene expression patterns which are governed by epigenetics can result in autoimmune diseases, cancers, and various other maladies. Mechanisms of epigenetics include DNA methylation (and demethylation), histone modifications, and non-coding RNAs such as microRNAs. Compared to numerous studies that have focused on the field of genetics, research on epigenetics is fairly recent. In contrast to ...
CONCLUSION: Radiological imaging is essential for the management of patients affected by lung cancer. PMID: 32445458 [PubMed - as supplied by publisher]
Condition: Non Small Cell Lung Cancer Intervention: Drug: TQ-B3139 Sponsor: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Not yet recruiting
Conditions: ICC; Metastatic Cancer Interventions: Drug: Folfirinox; Drug: Sintilimab Sponsor: Sun Yat-sen University Recruiting
Condition: Breast Cancer Invasive Interventions: Drug: Pyrotinib; Drug: Trastuzumab; Drug: Pertuzumab; Drug: Nab-paclitaxel; Drug: EC chemotherapy; Drug: Physician's choice; Drug: T-DM1; Procedure: Surgery Sponsors: Shanghai Jiao Tong University School of Medicine; Jiangsu HengRui Medicine Co., Ltd. Not yet recruiting
Conditions: Neuroendocrine Tumor; Anaplastic Thyroid Cancer; Adenocarcinoma; Pheochromocytoma; Paraganglioma Intervention: Drug: Cabozantinib 40 mg Sponsors: Grupo Espanol de Tumores Neuroendocrinos; Ipsen; Roche Pharma AG Not yet recruiting
Conditions: Solid Tumor; Gastric Cancer; Pancreatic Adenocarcinoma Intervention: Drug: AB011 Injection Sponsors: Carsgen Therapeutics, Ltd.; Shanghai East Hospital Not yet recruiting
Condition: Esophageal Cancer Interventions: Other: Injection of indocyanine green (ICG)dye; Device: Near-Infrared Image-Guided; Procedure: Sentinel Lymph Node (SNL) mapping Sponsor: Memorial Sloan Kettering Cancer Center Recruiting