Magnetic Resonance Elastography of Transplanted Kidney (GREFFE_ELASTO IRM)

Condition:   Interstitial Fibrosis/Tubular Atrophy of Transplanted Kidneys Intervention:   Device: MRE exam Sponsor:   University Hospital, Bordeaux Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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ConclusionPatients within Milan criteria have acceptable RFS even in the presence of poor prognostic factors. However, the presence of two or more poor prognostic variables significantly impacts RFS of patients outside Milan criteria.
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
Publication date: Available online 17 April 2019Source: Canadian Journal of DiabetesAuthor(s): Calvin Ke, S. Joseph Kim, Baiju R. Shah, Arlene S. Bierman, Lorraine L. Lipscombe, Denice S. Feig, Gillian L. BoothAbstractObjectivesTo determine whether low socioeconomic status (SES), with or without universal drug coverage, predicts end-stage renal disease (ESRD) and survival after dialysis in patients with diabetes.MethodsWe conducted a population-based retrospective cohort study in Ontario, Canada. We used ≥65 years of age as a surrogate for universal drug coverage. Adults with diabetes were followed from March 31, 1...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Publication date: Available online 23 May 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Priscila Dallé Rosa, Karla Sheid, Claudete Locatelli, Diane Marinho, Luciano GoldaniAbstractA case report of fungal keratitis caused by a multiresistant Fusarium solani in a tertiary care hospital located in southern Brazil. A 55-year-old man with a history of ocular trauma presented with keratitis in left eye. The patient has a complicated clinical course and failed to respond to local and systemic antifungal treatment, and required eye enucleation. Despite multiple topical, intraocular and systemic antifung...
Source: The Brazilian Journal of Infectious Diseases - Category: Infectious Diseases Source Type: research
AbstractPurpose of ReviewThe prevalence of heart failure (HF) continues to grow in the USA, and approximately 50% of these patients are women. Despite this, there has been an underrepresentation of women in HF clinical trials, which has led to limitations in understanding of sex-related differences in HF pathophysiology, diagnosis, and treatment. The purpose of this review is to highlight the differences between men and women in various heart failure trials conducted in the last century and emphasize new findings from recent trials in the management of, and outcomes in, women with HF.Recent FindingsHF trials have shown tha...
Source: Current Cardiovascular Risk Reports - Category: Cardiology Source Type: research
AbstractBackground The effects of mycophenolic acid exposure in the early period after transplantation on clinical outcomes have been reported; however, mycophenolic acid exposure in the early period after transplantation in Asian kidney transplant recipients who receive 1.5  g/d mycophenolate mofetil has never been investigated. Objective To determine mycophenolic acid exposure on day 3 post-transplantation in kidney transplant recipiens who receive 1.5 g/d mycophenolate mofetil. The effects of the reduced renal function on mycophenolic acid area under the concentrat ion–time curve (AUC) and the achievemen...
Source: International Journal of Clinical Pharmacy - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 29 April 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Yaohua Cao, Ning Wan, Zhuoru Liang, Jingmei Xie, Sen Wang, Tengfei Lin, Tiantian Zhang, Jie JiangAbstractMany new regimens have been applied to newly diagnosed transplant-ineligible multiple myeloma, but no head-to-head research has been performed to compare the efficacy of these treatments. Currently lenalidomide plus dexamethasone (Rd) is one of the standard treatments. Our aim was to make a comparison of these treatments to Rd by a network meta-analysis. We performed a systematic review and network meta-analysis. We ...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Publication date: Available online 23 May 2019Source: Stem Cell ReportsAuthor(s): Maher Hanoun, Anna Arnal-Estapé, Maria Maryanovich, Ali H. Zahalka, Sarah K. Bergren, Chee W. Chua, Avigdor Leftin, Patrik N. Brodin, Michael M. Shen, Chandan Guha, Paul S. FrenetteSummaryIn the prostate, stem and progenitor cell regenerative capacities have been ascribed to both basal and luminal epithelial cells. Here, we show that a rare subset of mesenchymal cells in the prostate are epithelial-primed Nestin-expressing cells (EPNECs) that can generate self-renewing prostate organoids with bipotential capacity. Upon transplantation,...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
ConclusionDonor hepatocytes (1 × 107/1mL) and SVF cells (1 × 106/0.5mL) were isolated from Tg(UBC–emGFP) rats and human adipose tissues, respectively, and were intraportally transplanted into ACLF rats. SVF cells were divided into CD34+ and CD34− groups. The surviving animals were sacrificed at 1 and 2 weeks after the transplantation. Gene expression levels, measured by quantitative real-time RT-PCR, were normalized against endogenous glyceraldehyde-3-phosphatedehydrogenase control.Histologically, prominent biliary ductular proliferation and significantly progression of fibrosis (P = 0.0...
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionWe could enrich Tregs to high purity: from 6.6% (±1.4%) in buffy coat samples to 54.1% (±20.9%) after CD25-immunomagnetic selection on a CliniMACS Plus device (Miltenyi Biotec), and to 95.3% (± 1.8%) purity after multiparametric FACS-sorting for CD4+CD25+CD127low Tregs (MacsQuant Tyto, Miltenyi Biotec). The purified Tregs could be expanded with CD3/CD28 activation in medium supplemented with interleukin-2 and rapamycin. We showed that Tregs could be successfully gene-marked with a clinically approved retroviral vector, SFG.iCasp9.2A.ΔCD19. The expanded gene-marked Tregs maintained a hig...
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionWe have used MSC-exo via intranasal administration to treat both BTBR and shank3 KO mice. The behavioral effect seemed 3 weeks post the treatment.The behavioral amelioration was seen in all the core symptoms including social interaction, repetitive behaviors, and vocal communication.
Source: Cytotherapy - Category: Cytology Source Type: research
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